In early multiple sclerosis, a clearer understanding of normal-brain tissue microstructural
and metabolic abnormalities will provide valuable insights into its pathophysiology. We used …

Multiple sclerosis (MS) is a chronic, demyelinating, not fully understood disease of the
central nervous system. The first demyelinating clinical episode is called clinically isolated …

BACKGROUND AND PURPOSE: A number of MR-derived quantitative metrics have been
suggested to assess the pathophysiology of MS, but the reports about combined analyses of …

Background As disease progression remains poorly understood in multiple sclerosis (MS),
we aim to investigate the sequence in which different disease milestones occur using a …

Introduction Circulating microRNAs are promising biomarkers for multiple sclerosis (MS).
Our aim was to correlate serum microRNA levels with various magnetic resonance imaging …

Normal appearing white matter (NAWM) damage develops early in multiple sclerosis (MS)
and continues in the absence of new lesions. The ratio of T1w and T2w (T1w/T2w ratio), a …

Objectives We aimed to characterize the brain abnormalities that are associated with the
cognitive and physical performance of patients with relapsing-remitting multiple sclerosis …

Background: Tract-based spatial statistics (TBSS) is suitable for the assessment of voxel-
wise changes in fiber integrity in WM tracts in the entire brain. Longitudinal TBSS analyses …

Background Mobility impairment is common in older persons with multiple sclerosis (MS),
and further compounded by general age-related mobility decline but its underlying brain …

Background Diffusion tensor imaging (DTI) is recommended as a sensitive method to
explore white matter (WM) microstructural alterations. Cerebral small vessel disease (CSVD) …