Overview of AlphaFold2 and breakthroughs in overcoming its limitations.

L Wang, Z Wen, SW Liu, L Zhang, C Finley… - Computers in Biology …, 2024 - Elsevier
Abstract Predicting three-dimensional (3D) protein structures has been challenging for
decades. The emergence of AlphaFold2 (AF2), a deep learning-based machine learning …

Benchmarking AlphaFold3's protein-protein complex accuracy and machine learning prediction reliability for binding free energy changes upon mutation

JJ Wee, GW Wei - arXiv preprint arXiv:2406.03979, 2024 - arxiv.org
AlphaFold 3 (AF3), the latest version of protein structure prediction software, goes beyond its
predecessors by predicting protein-protein complexes. It could revolutionize drug discovery …