[HTML][HTML] The role of Pcdh10 in neurological disease and cancer

Y Zhen, M Pavez, X Li - Journal of Cancer Research and Clinical …, 2023 - Springer
Abstract Background Protocadherin 10 (PCDH 10), a member of the superfamily of
protocadherins, is a Ca2+-dependent homophilic cell-cell adhesion molecule expressed on …

[HTML][HTML] Genetic and neural mechanisms of sleep disorders in children with autism spectrum disorder: a review

Q Ji, SJ Li, JB Zhao, Y Xiong, XH Du, CX Wang… - Frontiers in …, 2023 - frontiersin.org
Background The incidence of sleep disorders in children with autism spectrum disorder
(ASD) is very high. Sleep disorders can exacerbate the development of ASD and impose a …

[HTML][HTML] Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in …

A Pignataro, P Krashia, M De Introna, A Nobili… - Translational …, 2023 - nature.com
Female, but not male, mice with haploinsufficiency for the proautophagic Ambra1 gene show
an autistic-like phenotype associated with hippocampal circuits dysfunctions which include …

Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk

SB Gumusoglu, MD Kiel, A Gugel… - …, 2024 - nature.com
Psychiatric and obstetric diseases are growing threats to public health and share high rates
of co-morbidity. G protein-coupled receptor signaling (eg, vasopressin, serotonin) may be a …

[HTML][HTML] Gene editing in monogenic autism spectrum disorder: animal models and gene therapies

N Wang, L Lv, X Huang, M Shi, Y Dai, Y Wei… - Frontiers in Molecular …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disease, and its diagnosis
is dependent on behavioral manifestation, such as impaired reciprocal social interactions …

Altered socio-affective communication and amygdala development in mice with protocadherin10-deficient interneurons

T Aerts, A Boonen, L Geenen, A Stulens… - Open …, 2024 - royalsocietypublishing.org
Autism spectrum disorder (ASD) is a group of neurodevelopmental conditions associated
with deficits in social interaction and communication, together with repetitive behaviours …

BLA-involved circuits in neuropsychiatric disorders

LH Ma, S Li, XH Jiao, ZY Li, Y Zhou, CR Zhou… - Ageing Research …, 2024 - Elsevier
The basolateral amygdala (BLA) is the subregion of the amygdala located in the medial of
the temporal lobe, which is connected with a wide range of brain regions to achieve diverse …

[HTML][HTML] Cerebellar contributions to fear-based emotional processing: relevance to understanding the neural circuits involved in autism

S Couto-Ovejero, J Ye, PC Kind, SM Till… - Frontiers in Systems …, 2023 - frontiersin.org
Cerebellar networks have traditionally been linked to sensorimotor control. However, a large
body of evidence suggests that cerebellar functions extend to non-motor realms, such as …

[HTML][HTML] Analysis of the mechanism of propagated sensation along meridians based on gene expression profiles

X Zhu, J Xu, J Wang, Z Sa, X Pan, S Zheng… - Journal of Traditional and …, 2023 - Elsevier
Background and aim Propagated sensation along meridians (PSM) is an important basis for
the formation of the meridian theory, but its mechanism is still unclear. The study explored …

[HTML][HTML] Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms

I Kleinberger, E Sanders, K Staes, M Van Troys… - BMC cancer, 2022 - Springer
Background Nonclustered mouse protocadherin genes (Pcdh) encode proteins with a
typical single ectodomain and a cytoplasmic domain with conserved motifs completely …