Clinical electroencephalography for anesthesiologists: part I: background and basic signatures
The widely used electroencephalogram-based indices for depth-of-anesthesia monitoring
assume that the same index value defines the same level of unconsciousness for all …
assume that the same index value defines the same level of unconsciousness for all …
General anesthesia, sleep, and coma
General Anesthesia, Sleep, and Coma | New England Journal of Medicine Skip to main content
The New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
The New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
Sleep deprivation impairs molecular clearance from the human brain
It remains an enigma why human beings spend one-third of their life asleep. Experimental
data suggest that sleep is required for clearance of waste products from brain metabolism …
data suggest that sleep is required for clearance of waste products from brain metabolism …
[HTML][HTML] Rapid reconfiguration of the functional connectome after chemogenetic locus coeruleus activation
The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain and regulates
many fundamental brain functions. Studies in humans have suggested that strong LC …
many fundamental brain functions. Studies in humans have suggested that strong LC …
Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose …
H Benveniste, H Lee, F Ding, Q Sun, E Al-Bizri… - …, 2017 - pubs.asahq.org
Background The glymphatic pathway transports cerebrospinal fluid through the brain,
thereby facilitating waste removal. A unique aspect of this pathway is that its function …
thereby facilitating waste removal. A unique aspect of this pathway is that its function …
General anesthesia and altered states of arousal: a systems neuroscience analysis
EN Brown, PL Purdon… - Annual review of …, 2011 - annualreviews.org
Placing a patient in a state of general anesthesia is crucial for safely and humanely
performing most surgical and many nonsurgical procedures. How anesthetic drugs create …
performing most surgical and many nonsurgical procedures. How anesthetic drugs create …
Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological …
ER Samuels, E Szabadi - Current neuropharmacology, 2008 - ingentaconnect.com
The locus coeruleus (LC), the major noradrenergic nucleus of the brain, gives rise to fibres
innervating most structures of the neuraxis. Recent advances in neuroscience have helped …
innervating most structures of the neuraxis. Recent advances in neuroscience have helped …
IV and perineural dexmedetomidine similarly prolong the duration of analgesia after interscalene brachial plexus block: a randomized, three-arm, triple-masked …
Background Perineural and IV dexmedetomidine have each been suggested to prolong the
duration of analgesia when administered in conjunction with peripheral nerve blocks. In the …
duration of analgesia when administered in conjunction with peripheral nerve blocks. In the …
Current concepts in intracranial interstitial fluid transport and the glymphatic system: part I—anatomy and physiology
JM Klostranec, D Vucevic, KD Bhatia, HGJ Kortman… - Radiology, 2021 - pubs.rsna.org
Normal physiologic function of organs requires a circulation of interstitial fluid to deliver
nutrients and clear cellular waste products. Lymphatic vessels serve as collectors of this fluid …
nutrients and clear cellular waste products. Lymphatic vessels serve as collectors of this fluid …
Dexmedetomidine injection into the locus ceruleus produces antinociception
TZ Guo, JY Jiang, AE Buttermann… - The Journal of the …, 1996 - pubs.asahq.org
Background Alpha (2)-Adrenergic agonists such as clonidine and dexmedetomidine are
known to produce sedation and analgesia in humans. The sedative effect of these agents is …
known to produce sedation and analgesia in humans. The sedative effect of these agents is …