Triacylglycerol (TAG) is the most important caloric source with respect to energy
homeostasis in animals. In addition to its evolutionarily conserved importance as an energy …

Neurons possess a complex morphology spanning long distances and a large number of
subcellular specializations such as presynaptic terminals and dendritic spines. This …

Obesity is associated with cognitive decline. Recent observations in mice propose an
adipose tissue (AT)–brain axis. We identified 188 genes from RNA sequencing of AT in …

How adult neurons coordinate lipid metabolism to regenerate axons remains elusive. We
found that depleting neuronal lipin1, a key enzyme controlling the balanced synthesis of …

During infection, cellular resources are allocated toward the metabolically-demanding
processes of synthesizing and secreting effector proteins that neutralize and kill invading …

Axons in the adult mammalian nervous system can extend over formidable distances, up to
one meter or more in humans. During development, axonal and dendritic growth requires …

During differentiation, neurons require a high lipid supply for membrane formation as they
elaborate complex dendritic morphologies. While glia-derived lipids support neuronal …

Transcription factors (TFs) play essential roles in the transcriptional regulation of functional
genes, and are involved in diverse physiological processes in living organisms. The fruit fly …

Sleep behavior is conserved throughout evolution, and sleep disturbances are a frequent
comorbidity of neuropsychiatric disorders. However, the molecular basis underlying sleep …

Background Schizophrenia is a debilitating psychiatric disorder characterized by molecular
and anatomical abnormalities of multiple brain regions. Our recent study showed that …