Dementia is a clinical syndrome that affects approximately 47 million people worldwide and
is characterized by progressive and irreversible decline of cognitive, behavioral and …

Cerebral clearance of amyloid β‐protein (Aβ) is decreased in early‐onset and late‐onset
Alzheimer's disease (AD). Aβ is cleared from the brain by enzymatic degradation and by …

Cerebral ischemia causes damage to the structure and function of the blood‐brain barrier
(BBB) and alleviating BBB destruction will be of great significance for the treatment and …

The daily consumption of Extra Virgin Olive Oil (EVOO) in Mediterranean nutrition is tightly
associated with lower frequency of many diseases' appearance, including Alzheimer's …

Increased cerebrovascular amyloid-β (Aβ) deposition represents the main pathogenic
mechanisms characterizing Alzheimer's disease (AD) and cerebral amyloid angiopathy …

The neurovascular unit (NVU) is a dynamic structure assembled by endothelial cells
surrounded by a basement membrane, pericytes, astrocytes, microglia and neurons. A …

Urokinase-type plasminogen activator (uPA; encoded by Plau) is a serine proteinase that, in
the central nervous system, induces astrocytic activation. β-Catenin is a protein that links the …

Elucidating the pathogenic mechanisms of Alzheimer's disease (AD) to identify therapeutic
targets has been the focus of many decades of research. While deposition of extracellular …

Rationale Extracellular proteolytic activity plays an important role in memory formation and
the preservation of cognitive function. Previous studies have shown increased levels of …

The repair of injured tissue is a highly complex process that involves cell proliferation,
differentiation, and migration. Cell migration requires the dismantling of intercellular contacts …