Phenotypic and functional heterogeneity is one of the hallmarks of human cancers. Tumor
genotype variations among tumors within different patients are known as interpatient …

Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma and is
notorious for its heterogeneity, aggressive nature, and the frequent development of …

Axicabtagene ciloleucel (axi-cel) is an anti-CD19 chimeric antigen receptor (CAR) T cell
therapy approved for relapsed/refractory large B cell lymphoma (LBCL) and has treatment …

TET2 somatic mutations occur in∼ 10% of diffuse large B-cell lymphomas (DLBCL) but are
of unknown significance. Herein, we show that TET2 is required for the humoral immune …

Despite considerable advances in the treatment of lymphoma, the prognosis of patients with
relapsed and/or refractory disease continues to be poor; thus, a continued need exists for …

APOBEC proteins can deaminate cytosine residues in DNA and RNA. This can lead to
somatic mutations, DNA breaks, RNA modifications, or DNA demethylation in a selective …

Abstract HELLS/LSH (Helicase, Lymphoid Specific) is a SNF2-like chromatin remodelling
protein involved in DNA methylation. Its loss-of-function in humans causes humoral …

Activation induced cytidine deaminase (AID) protein is a member of APOBEC family. AID
converts cytidine to uracil, which is a key step for somatic hypermutation (SHM) and class …

DNA methyltransferases (DNMTs) are an evolutionarily conserved family of DNA
methylases, transferring a methyl group onto the fifth carbon of a cytosine residue. The …

Epidemiological evidence supports an association between cow's milk consumption and the
risk of diffuse large B-cell lymphoma (DLBCL), the most common non-Hodgkin lymphoma …