Metabolically healthy obesity: facts and fantasies

GI Smith, B Mittendorfer, S Klein - The Journal of clinical …, 2019 - Am Soc Clin Investig
Although obesity is typically associated with metabolic dysfunction and cardiometabolic
diseases, some people with obesity are protected from many of the adverse metabolic …

[HTML][HTML] Novel insights into the pathogenesis and management of the metabolic syndrome

HH Wang, DK Lee, M Liu, P Portincasa… - … , hepatology & nutrition, 2020 - ncbi.nlm.nih.gov
The metabolic syndrome, by definition, is not a disease but is a clustering of individual
metabolic risk factors including abdominal obesity, hyperglycemia, hypertriglyceridemia …

Intermuscular adipose tissue in metabolic disease

BH Goodpaster, BC Bergman, AM Brennan… - Nature Reviews …, 2023 - nature.com
Intermuscular adipose tissue (IMAT) is a distinct adipose depot described in early reports as
a 'fatty replacement'or 'muscle fat infiltration'that was linked to ageing and neuromuscular …

Effects of exercise and aging on skeletal muscle

G Distefano, BH Goodpaster - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
A substantial loss of muscle mass and strength (sarcopenia), a decreased regenerative
capacity, and a compromised physical performance are hallmarks of aging skeletal muscle …

Ovarian hormones and obesity

B Leeners, N Geary, PN Tobler… - Human reproduction …, 2017 - academic.oup.com
BACKGROUND Obesity is caused by an imbalance between energy intake, ie eating and
energy expenditure (EE). Severe obesity is more prevalent in women than men worldwide …

Relationships between rodent white adipose fat pads and human white adipose fat depots

DE Chusyd, D Wang, DM Huffman, TR Nagy - Frontiers in nutrition, 2016 - frontiersin.org
The objective of this review was to compare and contrast the physiological and metabolic
profiles of rodent white adipose fat pads with white adipose fat depots in humans. Human fat …

Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes

F Karpe, KE Pinnick - Nature Reviews Endocrinology, 2015 - nature.com
The distribution of adipose tissue in the body has wide-ranging and reproducible
associations with health and disease. Accumulation of adipose tissue in the upper body …

Intermuscular fat: a review of the consequences and causes

O Addison, RL Marcus, PC LaStayo… - International journal of …, 2014 - Wiley Online Library
Muscle's structural composition is an important factor underlying muscle strength and
physical function in older adults. There is an increasing amount of research to support the …

Human T cell immunosenescence and inflammation in aging

A Bektas, SH Schurman, R Sen… - Journal of leukocyte …, 2017 - Wiley Online Library
The aging process is driven by a finite number of inter‐related mechanisms that ultimately
lead to the emergence of characteristic phenotypes, including increased susceptibility to …

[HTML][HTML] Mechanisms and metabolic implications of regional differences among fat depots

T Tchkonia, T Thomou, YI Zhu, I Karagiannides… - Cell metabolism, 2013 - cell.com
Fat distribution is closely linked to metabolic disease risk. Distribution varies with sex,
genetic background, disease state, certain drugs and hormones, development, and aging …