A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

DB Kell, GJ Laubscher, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Post-acute sequelae of COVID (PASC), usually referred to as 'Long COVID'(a phenotype of
COVID-19), is a relatively frequent consequence of SARS-CoV-2 infection, in which …

A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences

T Tyagi, K Jain, SX Gu, M Qiu, VW Gu… - Nature cardiovascular …, 2022 - nature.com
Platelets have been shown to be associated with pathophysiological processes beyond
thrombosis, demonstrating critical additional roles in homeostatic processes, such as …

High-throughput fluorescence lifetime imaging flow cytometry

H Kanno, K Hiramatsu, H Mikami… - Nature …, 2024 - nature.com
Flow cytometry is a vital tool in biomedical research and laboratory medicine. However, its
accuracy is often compromised by undesired fluctuations in fluorescence intensity. While …

Association between antidepressant use and ED or hospital visits in outpatients with SARS-CoV-2

BA Fritz, N Hoertel, EJ Lenze, F Jalali… - Translational …, 2022 - nature.com
Antidepressants have previously been associated with better outcomes in patients
hospitalized with COVID-19, but their effect on clinical deterioration among ambulatory …

Platelet aggregates detected using quantitative phase imaging associate with COVID-19 severity

C Klenk, J Erber, D Fresacher, S Röhrl… - Communications …, 2023 - nature.com
Background The clinical spectrum of acute SARS-CoV-2 infection ranges from an
asymptomatic to life-threatening disease. Considering the broad spectrum of severity …

The pathological maelstrom of COVID-19 and cardiovascular disease

M Giacca, AM Shah - Nature Cardiovascular Research, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a consequence of infection of the upper
and lower respiratory tract with severe acute respiratory syndrome coronavirus 2 but often …

Coagulopathy and fibrinolytic pathophysiology in COVID-19 and SARS-CoV-2 vaccination

S Yamada, H Asakura - International Journal of Molecular Sciences, 2022 - mdpi.com
Coronavirus Disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) and is frequently complicated by thrombosis. In some cases of …

Variation in presepsin and thrombomodulin levels for predicting COVID-19 mortality

A Yamazaki, Y Nukui, T Kameda, R Saito, Y Koda… - Scientific Reports, 2023 - nature.com
Abstract Coronavirus disease (COVID-19) has caused extensive mortality globally;
therefore, biomarkers predicting the severity and prognosis of COVID-19 are essential. This …

Real-time fluorescence imaging flow cytometry enabled by motion deblurring and deep learning algorithms

Y Wang, Z Huang, X Wang, F Yang, X Yao, T Pan, B Li… - Lab on a Chip, 2023 - pubs.rsc.org
Fluorescence imaging flow cytometry (IFC) has been demonstrated as a crucial biomedical
technique for analyzing specific cell subpopulations from heterogeneous cellular …

Studying the efficacy of antiplatelet drugs on atherosclerosis by optofluidic imaging on a chip

Y Deng, HM Tay, Y Zhou, X Fei, X Tang, M Nishikawa… - Lab on a Chip, 2023 - pubs.rsc.org
Vascular stenosis caused by atherosclerosis instigates activation and aggregation of
platelets, eventually resulting in thrombus formation. Although antiplatelet drugs are …