More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila
melanogaster. Later, a group of diverse genes collectively called Polycomb group (PcG) …

Recent genomic studies have resulted in an emerging understanding of the role of
chromatin regulators in the development of cancer. EZH2, a histone methyl transferase …

BACKGROUND Multicellular organisms depend on the precise orchestration of gene
expression to direct embryonic development and to maintain tissue homeostasis through …

GWAS have identified> 200 risk loci for Inflammatory Bowel Disease (IBD). The majority of
disease associations are known to be driven by regulatory variants. To identify the putative …

Polycomb Group (PcG) proteins are transcriptional repressors that epigenetically modify
chromatin and participate in the establishment and maintenance of cell fates. These proteins …

Enhancer of Zeste [E (z)] is a Polycomb-group transcriptional repressor and one of the
founding members of the family of SET domain-containing proteins. Several SET-domain …

Control of gene expression is exerted at a number of different levels, one of which is the
accessibility of genes and their controlling elements to the transcriptional machinery …

Tropomyosin receptor kinase (Trk) inhibitors have shown high response rates in patients
with tumors harboring NTRK fusions. We identified 4 NTRK fusion-positive uterine sarcomas …

Recent experiments have demonstrated that the Polycomb group (PcG) gene EZH2 is highly
expressed in metastatic prostate cancer and in lymphomas. EZH2 is a component of the …

Epigenetic regulation is critical to physiological control of development, cell fate, cell
proliferation, genomic integrity and, fundamentally, transcriptional regulation. This …