Main conclusion Plant tissue culture as an important tool for the continuous production of
active compounds including secondary metabolites and engineered molecules. Novel …

Cancer is one of the leading causes of death across the world. Different environmental and
anthropogenic factors initiate mutations in different functional genes of growth factors and …

The use of plant secondary metabolites has gained considerable attention among clinicians
in the prevention and treatment of cancer. A secondary metabolite isolated mainly from the …

Biotechnology is playing a vital alternative role in the production of pharmaceutical plant
secondary metabolites to support industrial production and mitigate over-exploitation of …

Natural products (NPs) are important sources of clinical drugs due to their structural diversity
and biological prevalidation. However, the structural complexity of NPs leads to synthetic …

Cancer is a worldwide scourge; it's the leading cause of death in developed countries and is
increasing in developing countries. Mankind has been trying with effort to find better and …

Several podophyllotoxin derivatives modified in the A, B, C, D and E rings were prepared
from podophyllotoxin and methyl isoxazopodophyllic acid and evaluated for their cytotoxicity …

Objective: The aim of the present review is to give an overview about the role, biosynthesis,
and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular …

The lignan podophyllotoxin (1) is highly valued as the precursor to clinically useful
anticancer drugs. Substantial drug development of this compound class continues, including …

The aryl tetralin lignans are synthesized by Podophyllum sps. and are in great demand
worldwide due to their use in synthesis of topoisomerase inhibitors. However, the sustained …