Despite advances in neuroscience, limited progress has been made in developing new and
better medications for psychiatric disorders. Available treatments in psychiatry rely on a few …

Depression is a heterogeneous mental disorder characterized by feelings of sadness and
loss of interest that render the subject unable to handle basic daily activities such as …

Frailty and depression were linked in observational studies, but the causality remains
ambiguous. We intended to explore it using Mendelian randomization (MR). We obtained …

Depression onset peaks during adolescence and young adulthood. Current treatments are
only moderately effective, driving the search for novel pathophysiological mechanisms …

Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward
motivation, and/or deficits in reward-related learning, is a common feature of depression …

Ischemic Stroke precedes depression. Post-stroke depression (PSD) is a major driver for
poor recovery, negative quality of life, poor rehabilitation outcomes and poor functional …

The relationship between emotional states and immune system activity is characterized by
bidirectional influences; however, limited information is available regarding the temporal …

Patients with cancer are at greater risk of developing depression in comparison to the
general population and this is associated with serious adverse effects, such as poorer …

Stroke is a leading cause of mortality and disability worldwide, with most survivors reporting
dysfunctions of motor, sensation, deglutition, cognition, emotion, and speech, etc. Repetitive …

Objectives Obesity is associated with an increased risk of depression. Systemic low-grade
inflammation, a plausible consequence of obesity, has also been linked to depression …