Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

Publisher Summary This chapter discusses the role of free radicals and catalytic metal ions
in human disease. The importance of transition metal ions in mediating oxidant damage …

The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the
clinical management of gout and conditions associated with hyperuricemia for several …

There is substantial evidence that oxidative stress participates in the pathophysiology of
cardiovascular disease. Biochemical, molecular and pharmacological studies further …

The intestine constitutes the largest interface between a person and his or her environment,
and an intact intestinal barrier is thus essential in maintaining health and preventing tissue …

Reperfusion of ischemic intestine leads to a sequence of events that paradoxically results in
tissue injury. Reperfusion following short periods of ischemia causes alterations in …

Mucosal repair is a complex event that immediately follows acute injury induced by ischemia
and noxious luminal contents such as bile. In the small intestine, villous contraction is the …

Research in the field of ischemia-reperfusion injury continues to be plagued by the inability
to translate research findings to clinically useful therapies. This may in part relate to the …

Numerous studies indicate that moderate red wine consumption is associated with a
protective effect against all-cause mortality. Since oxidative stress constitutes a unifying …

There is increasing interest in nonrodent translational models for the study of human
disease. The pig, in particular, serves as a useful animal model for the study of …