BACKGROUND During early mammalian brain development, transient neurons and circuits
form the scaffold for the development of neuronal networks. In the immature cerebral cortex …

Electrical activity in neurons requires a seamless functional coupling between
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …

Neonatal hypoxia-ischaemia (HI) is the most common cause of death and disability in
human neonates, and is often associated with persistent motor, sensory, and cognitive …

GABA is the major inhibitory neurotransmitter that counterbalances excitation in the mature
brain. The inhibitory action of GABA relies on the inflow of chloride ions (Cl−), which …

The human brain develops slowly and over a long period of time which lasts for almost three
decades. This enables good spatio-temporal resolution of histogenetic and neurogenetic …

Autism is a common and heterogeneous childhood neurodevelopmental disorder.
Analogous to broad syndromes such as mental retardation, autism has many etiologies and …

Recent years have witnessed a steep increase in studies on the diverse roles of neuronal
cation-chloride cotransporters (CCCs). The versatility of CCC gene transcription …

Patterns of synaptic connections in the visual system are remarkably precise. These
connections dictate the receptive field properties of individual visual neurons and ultimately …

In many regions of the developing brain, neuronal circuits undergo defined phases of
enhanced plasticity, termed critical periods. Work in the rodent visual cortex has led to …

Subplate neurons have an essential role in cortical circuit formation. They are among the
earliest formed neurons of the cerebral cortex, are located at the junction of white and grey …