Desert endemic plants in Algeria: A review on traditional uses, phytochemistry, polyphenolic compounds and pharmacological activities

H Hemmami, BB Seghir, S Zeghoud, I Ben Amor… - Molecules, 2023 - mdpi.com
Due to their robust antioxidant capabilities, potential health benefits, wide variety of
biological activities, and strong antioxidant qualities, phenolic compounds are substances …

Synthesis and biological evaluation of organoselenium (NSAIDs-SeCN and SeCF3) derivatives as potential anticancer agents

X He, M Zhong, S Li, X Li, Y Li, Z Li, Y Gao… - European Journal of …, 2020 - Elsevier
A series of organoselenium compounds based on the hybridization of nonsteroidal
antiinflammatory drugs (NSAIDs) scaffolds and Se functionalities (-SeCN and-SeCF 3) were …

Synthesis and biochemical studies of novel organic selenides with increased selectivity for hepatocellular carcinoma and breast adenocarcinoma

S Shaaban, AM Ashmawy, A Negm… - European Journal of …, 2019 - Elsevier
Nineteen organoselenides were synthesized and tested for their intrinsic cytotoxicity in
hepatocellular carcinoma (HepG2) and breast adenocarcinoma (MCF-7) cell lines and their …

New organoselenides (NSAIDs-Se derivatives) as potential anticancer agents: Synthesis, biological evaluation and in silico calculations

X He, Y Nie, M Zhong, S Li, X Li, Y Guo, Z Liu… - European Journal of …, 2021 - Elsevier
Herein we reported the synthesis of twenty new organoselenium compounds (2a-2j and 3a-
3j) based on the hybridization of nonsteroidal antiinflammatory drugs (NSAIDs) skeleton and …

The genus Genista L.: A rich source of bioactive flavonoids

ME Grafakou, C Barda, EM Tomou, H Skaltsa - Phytochemistry, 2021 - Elsevier
The genus Genista L.(family Fabaceae, subfamily Papilionoideae), with its cosmopolitan
distribution, has attracted the human interest since ancient times, as it is used in folk …

Combinatorial synthesis, in silico, molecular and biochemical studies of tetrazole-derived organic selenides with increased selectivity against hepatocellular …

S Shaaban, A Negm, AM Ashmawy, DM Ahmed… - European Journal of …, 2016 - Elsevier
Novel tetrazole-based diselenides and selenoquinones were synthesized via azido-Ugi and
sequential nucleophilic substitution (SN) strategy. Molecular docking study into mammalian …

Organoselenocyanates and symmetrical diselenides redox modulators: Design, synthesis and biological evaluation

S Shaaban, A Negm, MA Sobh… - European journal of …, 2015 - Elsevier
Oxidative stress (OS) and disturbed intracellular redox balance have been predominantly
observed in different types of cancer, including hepatocellular carcinoma (HCC). Agents …

[HTML][HTML] Cytoprotective organoselenium compounds for oligodendrocytes

S Shaaban, A Zarrouk, D Vervandier-Fasseur… - Arabian Journal of …, 2021 - Elsevier
Herein we report the synthesis of peptide-like and tetrazole-based organoselenium
compounds via Ugi and Ugi-azide reactions, respectively. The organoselenium compounds' …

Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines

MA Ismail, A Negm, RK Arafa, E Abdel-Latif… - European Journal of …, 2019 - Elsevier
A series of thirteen new aryl/hetarylbichalcophene-5-carboxamidines was prepared and
screened for an in vitro anti-proliferative activity against sixty cancer cell lines. The tested …

Expeditious entry to functionalized pseudo-peptidic organoselenide redox modulators via sequential Ugi/SN methodology

S Shaaban, A Negm, M A. Sobh… - Anti-Cancer Agents in …, 2016 - benthamdirect.com
An efficient route towards the synthesis of symmetrical diselenide and seleniumcontaining
quinone pseudopeptides via one-pot Ugi and sequential nucleophilic substitution (SN) …