Epidemiological studies have shown a dramatic increase in the incidence and the
prevalence of allergic diseases over the last several decades. Environmental triggers …

Unbiased genetic approaches, especially genome-wide association studies, have identified
novel genetic targets in the pathogenesis of asthma, but so far these targets account for only …

Allergic diseases, characterized by a broad spectrum of clinical manifestations and
symptoms, encompass a significant category of IgE-mediated atopic disorders, including …

It has been recognized for centuries that allergic disease runs in families, implying a role for
genetic factors in determining individual susceptibility. More recently, a range of evidence …

Background: Keloids are benign fibrous growths that are caused by excessive tissue build-
up. Severe keloids exert more significant effects on patients' quality of life than do mild …

Background Season of birth influences allergy risk; however, the biological mechanisms
underlying this observation are unclear. The environment affects DNA methylation, with …

Histone deacetylase 1 (HDAC1) is a unique member of the classes I HDACs and helps to
regulate acute and chronic adaptation to environmental stimuli such as allergen, stress …

Several studies have investigated the relationship between genetic variation and DNA
methylation with respect to type 2 diabetes, but it is unknown if DNA methylation is a …

Epigenetics has widespread implications in a variety of cellular processes ranging from cell
identity and specification, to cellular adaptation to environmental stimuli. While typically …

Infectious hematopoietic necrosis (IHN) is a significant viral disease affecting salmonids,
whereas Flavobacterium psychrophilum (Fp), the causative agent of bacterial coldwater …