Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Ischemic stroke is one of the significant causes of morbidity and mortality, affecting millions
of people across the globe. Cell injury in the infarct region is an inevitable consequence of …

Glaucoma is a group of diseases characterized by progressive optic nerve degeneration that
results in visual field loss and irreversible blindness. A crucial element in the …

Stroke most commonly results from occlusion of a major artery in the brain and typically
leads to the death of all cells within the affected tissue. Mitochondria are centrally involved in …

It has long been recognized that much of the post-traumatic degeneration of the spinal cord
following injury is caused by a multi-factorial secondary injury process that occurs during the …

Microglia and infiltrating leukocytes are considered major producers of tumor necrosis factor
(TNF), which is a crucial player in cerebral ischemia and brain inflammation. We have …

Focal ischemia by middle cerebral artery occlusion (MCAO) results in necrosis at the infarct
core and activation of complex signal pathways for cell death and cell survival in the …

Cerebral ischemia leads to brain damage caused by pathogenetic mechanisms that are also
activated by neurotrauma. These mechanisms include among others excitotoxicity, over …