Anthracyclines are the cornerstone of many chemotherapy regimens for a variety of cancers.
Unfortunately, their use is limited by a cumulative dose-dependent cardiotoxicity. Despite …

Cancer remains a major public health problem worldwide and was responsible for 9.6
million deaths in 2018. Oncologic treatments such as doxorubicin (Dox) and trastuzumab …

Aims The mitochondria are important sources of reactive oxygen species (ROS) in the heart.
Mitochondrial ROS production has been implicated in the pathogenesis of diabetic …

Background Anthracycline chemotherapeutics, such as doxorubicin, are used widely in the
treatment of numerous malignancies. The primary dose-limiting adverse effect of …

Calpain plays a critical role in cardiomyopathic changes in type 1 diabetes (T1D). This study
investigated how calpain regulates mitochondrial reactive oxygen species (ROS) generation …

Septic acute kidney injury (AKI) and myocardial dysfunction are leading causes of mortality
with no accepted method of therapy. In this study we demonstrate the role of growth …

Cardiovascular diseases are the leading cause of death worldwide. Aging and/or metabolic
stress directly impact the cardiovascular system. Over the last few years, the contributions of …

Calpains are a family of cysteine proteases, implicated in a wide range of cellular calcium‑
regulated functions. Evidence from previous studies using an inhibitor of calpain indicates …

Background ER (endoplasmic reticulum) stress leads to decreased complex I activity in
cardiac mitochondria. The aim of the current study is to explore the potential mechanisms by …

Abstract Calpain 1 and 2 (CPN1/2) are calcium-dependent cysteine proteases that exist in
cytosol and mitochondria. Pharmacologic inhibition of CPN1/2 decreases cardiac injury …