Preventing and treating anthracycline cardiotoxicity: new insights
Anthracyclines are the cornerstone of many chemotherapy regimens for a variety of cancers.
Unfortunately, their use is limited by a cumulative dose-dependent cardiotoxicity. Despite …
Unfortunately, their use is limited by a cumulative dose-dependent cardiotoxicity. Despite …
Effects of doxorubicin on the heart: From molecular mechanisms to intervention strategies
N Prathumsap, K Shinlapawittayatorn… - European journal of …, 2020 - Elsevier
Cancer remains a major public health problem worldwide and was responsible for 9.6
million deaths in 2018. Oncologic treatments such as doxorubicin (Dox) and trastuzumab …
million deaths in 2018. Oncologic treatments such as doxorubicin (Dox) and trastuzumab …
Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy
Aims The mitochondria are important sources of reactive oxygen species (ROS) in the heart.
Mitochondrial ROS production has been implicated in the pathogenesis of diabetic …
Mitochondrial ROS production has been implicated in the pathogenesis of diabetic …
Doxorubicin exposure causes subacute cardiac atrophy dependent on the striated muscle–specific ubiquitin ligase MuRF1
Background Anthracycline chemotherapeutics, such as doxorubicin, are used widely in the
treatment of numerous malignancies. The primary dose-limiting adverse effect of …
treatment of numerous malignancies. The primary dose-limiting adverse effect of …
Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type 1 diabetic hearts: a novel mechanism contributing to diabetic …
Calpain plays a critical role in cardiomyopathic changes in type 1 diabetes (T1D). This study
investigated how calpain regulates mitochondrial reactive oxygen species (ROS) generation …
investigated how calpain regulates mitochondrial reactive oxygen species (ROS) generation …
Growth differentiation factor-15 deficiency augments inflammatory response and exacerbates septic heart and renal injury induced by lipopolysaccharide
P Abulizi, N Loganathan, D Zhao, T Mele, Y Zhang… - Scientific reports, 2017 - nature.com
Septic acute kidney injury (AKI) and myocardial dysfunction are leading causes of mortality
with no accepted method of therapy. In this study we demonstrate the role of growth …
with no accepted method of therapy. In this study we demonstrate the role of growth …
Therapeutic potential of emerging NAD+-increasing strategies for cardiovascular diseases
N Rotllan, M Camacho, M Tondo, EMG Diarte-Añazco… - Antioxidants, 2021 - mdpi.com
Cardiovascular diseases are the leading cause of death worldwide. Aging and/or metabolic
stress directly impact the cardiovascular system. Over the last few years, the contributions of …
stress directly impact the cardiovascular system. Over the last few years, the contributions of …
Critical role of calpain in inflammation
J Ji, L Su, Z Liu - Biomedical reports, 2016 - spandidos-publications.com
Calpains are a family of cysteine proteases, implicated in a wide range of cellular calcium‑
regulated functions. Evidence from previous studies using an inhibitor of calpain indicates …
regulated functions. Evidence from previous studies using an inhibitor of calpain indicates …
Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload
AA Mohsin, J Thompson, Y Hu, J Hollander… - Archives of Biochemistry …, 2020 - Elsevier
Background ER (endoplasmic reticulum) stress leads to decreased complex I activity in
cardiac mitochondria. The aim of the current study is to explore the potential mechanisms by …
cardiac mitochondria. The aim of the current study is to explore the potential mechanisms by …
Calpain-mediated protein targets in cardiac mitochondria following ischemia–reperfusion
Abstract Calpain 1 and 2 (CPN1/2) are calcium-dependent cysteine proteases that exist in
cytosol and mitochondria. Pharmacologic inhibition of CPN1/2 decreases cardiac injury …
cytosol and mitochondria. Pharmacologic inhibition of CPN1/2 decreases cardiac injury …