Cellular and molecular mechanisms of insulin resistance
P Chandrasekaran, R Weiskirchen - Current Tissue Microenvironment …, 2024 - Springer
Abstract Purpose of Review Although the molecular mechanism of insulin resistance
involves multiple factors and several intrinsic and extrinsic mechanisms have been …
involves multiple factors and several intrinsic and extrinsic mechanisms have been …
Unraveling the rationale and conducting a comprehensive assessment of KD025 (Belumosudil) as a candidate drug for inhibiting adipogenic differentiation—a …
SM Barbalho, R de Alvares Goulart, G Minniti… - Naunyn-Schmiedeberg's …, 2024 - Springer
Rho-associated kinases (ROCKs) are crucial during the adipocyte differentiation process.
KD025 (Belumosudil) is a newly developed inhibitor that selectively targets ROCK2. It has …
KD025 (Belumosudil) is a newly developed inhibitor that selectively targets ROCK2. It has …
Deficiency of Brummer lipase disturbs lipid mobilization and locomotion, and impairs reproduction due to defects in the eggshell ultrastructure in the insect vector …
DS Arêdes, T Rios, LF Carvalho-Kelly, V Braz… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Rhodnius prolixus is a hematophagous insect, which feeds on large and infrequent blood
meals, and is a vector of trypanosomatids that cause Chagas disease. After feeding, lipids …
meals, and is a vector of trypanosomatids that cause Chagas disease. After feeding, lipids …
Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status
A Nandy, RCM Helderman, S Thapa, S Jayapalan… - Bone research, 2023 - nature.com
Bone formation is a highly energy-demanding process that can be impacted by metabolic
disorders. Glucose has been considered the principal substrate for osteoblasts, although …
disorders. Glucose has been considered the principal substrate for osteoblasts, although …
Anti-obesity effect and mechanism of chitooligosaccharides were revealed based on lipidomics in diet-induced obese mice
M Zhou, J Huang, J Zhou, C Zhi, Y Bai, Q Che, H Cao… - Molecules, 2023 - mdpi.com
Chitooligosaccharide (COS) is a natural product from the ocean, and while many studies
have reported its important role in metabolic diseases, no study has systematically …
have reported its important role in metabolic diseases, no study has systematically …
Oral administration of PIISVYWK and FSVVPSPK peptides attenuates obesity, oxidative stress, and inflammation in high fat diet-induced obese mice
IT Suryaningtyas, CK Marasinghe, B Lee… - The Journal of Nutritional …, 2025 - Elsevier
The bioactive peptides PIISVYWK (P1) and FSVVPSPK (P2), derived from the blue mussel
Mytilus edulis, exhibit significant benefits in combating obesity, oxidative stress, and …
Mytilus edulis, exhibit significant benefits in combating obesity, oxidative stress, and …
[HTML][HTML] Reducing the lipase LIPE in mutant α-synuclein mice improves Parkinson-like deficits and reveals sex differences in fatty acid metabolism
MA Adom, WN Hahn, TD McCaffery, TE Moors… - Neurobiology of …, 2024 - Elsevier
Impaired lipid metabolism is a risk factor for Parkinson's disease (PD) and dementia with
Lewy bodies (DLB) and can shift the physiological α-synuclein (αS) tetramer-monomer (T …
Lewy bodies (DLB) and can shift the physiological α-synuclein (αS) tetramer-monomer (T …
Anti-seizure effects of norepinephrine-induced free fatty acid release
B Li, Q Sun, F Ding, Q Xu, N Kang, Y Xue… - Cell Metabolism, 2024 - cell.com
The brain's ability to rapidly transition between sleep, quiet wakefulness, and states of high
vigilance is remarkable. Cerebral norepinephrine (NE) plays a key role in promoting …
vigilance is remarkable. Cerebral norepinephrine (NE) plays a key role in promoting …
First transcriptome analysis of the venom glands of the scorpion Hottentotta zagrosensis (Scorpions: Buthidae) with focus on venom lipolysis activating peptides
F Salabi, H Jafari, M Mahdavinia… - Frontiers in …, 2024 - frontiersin.org
Introduction Scorpion venom is a rich source of biological active peptides and proteins.
Transcriptome analysis of the venom gland provides detailed insights about peptide and …
Transcriptome analysis of the venom gland provides detailed insights about peptide and …
[HTML][HTML] The BET inhibitor JQ1 targets fat metabolism and counteracts obesity
C Fornelli, AS Cento, L Nevi, R Mastrocola… - Journal of Advanced …, 2024 - Elsevier
Introduction Obesity, one of the most frequent health problems in the adult population, is a
condition characterized by excessive white adipose tissue accumulation and accompanied …
condition characterized by excessive white adipose tissue accumulation and accompanied …