Importance Uncontrolled and indiscriminate prescribing of opioids has led to an opioid crisis
that started in North America and spread throughout high-income countries. The aim of this …

Opioid-free anesthesia (OFA) is used in surgery to avoid opioid-related side effects.
However, uncertainty exists in the balance between OFA benefits and risks. We searched for …

Changes in clothing, automobiles, and restaurants follow popular trends and are often
periodic and cyclical. Ideally, medical change is driven not by fashion but instead by …

Study objective To evaluate all available evidence thus far on opioid based versus opioid-
free anesthesia and its effect on acute and chronic postoperative pain. Design Systematic …

Perioperative Opioids, the Opioid Crisis, and the Anesthesiologist | Anesthesiology | American
Society of Anesthesiologists Skip to Main Content Advertisement Umbrella Alt Text Umbrella Alt …

Anesthesia for laparoscopic sleeve gastrectomy and perioperative management remains a
challenge. Several clinical studies indicate that opioid-free anesthesia (OFA) may be …

BACKGROUND: The effectiveness and safety of opioid-free anesthesia (OFA) regimens in
distinct types of surgeries remain controversial. In this study, we investigated whether OFA …

Dexmedetomidine, a highly selective α2-adrenoceptor agonist, has sedative, anxiolytic,
analgesic, sympatholytic, and opioid-sparing properties and induces a unique sedative …

Purpose Opioid-free anesthesia (OFA) is an alternative to conventional opioid-based
anesthesia (OBA) in patients undergoing bariatric surgery. Several small studies and a meta …

Background Opioid-free anesthesia (OFA) is associated with significantly reduced
cumulative postoperative morphine consumption in comparison with opioid-based …