The gut-liver axis in liver disease: Pathophysiological basis for therapy

A Albillos, A De Gottardi, M Rescigno - Journal of hepatology, 2020 - Elsevier
The gut-liver axis refers to the bidirectional relationship between the gut and its microbiota,
and the liver, resulting from the integration of signals generated by dietary, genetic and …

Chemically and biologically engineered bacteria‐based delivery systems for emerging diagnosis and advanced therapy

Z Li, Y Wang, J Liu, P Rawding, J Bu… - Advanced …, 2021 - Wiley Online Library
Bacteria are one of the main groups of organisms, which dynamically and closely participate
in human health and disease development. With the integration of chemical biotechnology …

EASL Clinical Practice Guidelines on the management of hepatic encephalopathy

S Montagnese, PE Rautou, M Romero-Gómez… - Journal of …, 2022 - Elsevier
Summary The EASL Clinical Practice Guidelines (CPGs) on the management of hepatic
encephalopathy (HE) present evidence-based answers to a set of relevant questions (where …

Contribution of the intestinal microbiome and gut barrier to hepatic disorders

DM Chopyk, A Grakoui - Gastroenterology, 2020 - Elsevier
Intestinal barrier dysfunction and dysbiosis contribute to development of diseases in liver
and other organs. Physical, immunologic, and microbiologic (bacterial, fungal, archaeal …

[HTML][HTML] Gut microbiome diversity is associated with sleep physiology in humans

RP Smith, C Easson, SM Lyle, R Kapoor, CP Donnelly… - PloS one, 2019 - journals.plos.org
The human gut microbiome can influence health through the brain-gut-microbiome axis.
Growing evidence suggests that the gut microbiome can influence sleep quality. Previous …

The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications

JR Allegretti, BH Mullish, C Kelly, M Fischer - The Lancet, 2019 - thelancet.com
Developments in high-throughput microbial genomic sequencing and other systems biology
techniques have given novel insight into the potential contribution of the gut microbiota to …

Safety and efficacy of fecal microbiota transplantation for treatment of systemic lupus erythematosus: An EXPLORER trial

C Huang, P Yi, M Zhu, W Zhou, B Zhang, X Yi… - Journal of …, 2022 - Elsevier
Gut microbiota dysbiosis is involved in the development of systemic lupus erythematosus
(SLE). The safety and efficacy of fecal microbiota transplantation (FMT) for the treatment of …

Utilizing the gut microbiome in decompensated cirrhosis and acute-on-chronic liver failure

J Trebicka, P Bork, A Krag, M Arumugam - … reviews Gastroenterology & …, 2021 - nature.com
The human gut microbiome has emerged as a major player in human health and disease.
The liver, as the first organ to encounter microbial products that cross the gut epithelial …

A randomized clinical trial of fecal microbiota transplant for alcohol use disorder

JS Bajaj, EA Gavis, A Fagan, JB Wade… - …, 2021 - Wiley Online Library
Background and Aims Alcohol use disorder (AUD) is associated with microbial alterations
that worsen with cirrhosis. Fecal microbiota transplant (FMT) could be a promising approach …

[PDF][PDF] Fecal microbial transplant capsules are safe in hepatic encephalopathy: a phase 1, randomized, placebo‐controlled trial

JS Bajaj, NH Salzman, C Acharya, RK Sterling… - …, 2019 - Wiley Online Library
Hepatic encephalopathy (HE) can cause major morbidity despite standard of care (SOC;
rifaximin/lactulose). Fecal microbial transplant (FMT) enemas postantibiotics are safe, but …