Context Antiresorptive therapy significantly reduces fracture risk in patients with benign bone
disease and skeletal-related events (SREs) in patients with bone metastases (BM) …

Medication related osteonecrosis of the jaws (MRONJ) and osteoradionecrosis of the jaws
(ORNJ) are two different diseases of quite similar appearance. MRONJ is mainly due to …

Medication-related osteonecrosis of the jaw (MRONJ) is defined by the American
Association of Oral and Maxillofacial Surgeons (AAOMS) as the presence of an exposed …

Classically, osteoclast fusion consists of four basic steps:(1) attraction/migration,(2)
recognition,(3) cell–cell adhesion, and (4) membrane fusion. In theory, this sounds like a …

Objective This manuscript aims to provide a comprehensive review of the current knowledge
in the pathophysiology, diagnosis, prevention, and other relevant forensic and clinical …

Medication-related osteonecrosis of the jaw (MRONJ), a severe side effect caused by
antiresorptive antiangiogenic medication, particularly bisphosphonates (BPs), has become a …

Targeting excessive osteoclast differentiation and activity is considered a valid therapeutic
approach for osteoporosis. Zoledronic acid (ZOL) plays a pivotal role in regulating bone …

Osteoclasts play an important role in maintaining the relative stability of bone mass.
Abnormal number and function of osteoclasts are closely related to osteoporosis and …

RNA-binding protein 3 (RBMS3) plays a significant role in embryonic development and the
pathogenesis of many diseases, especially cancer initiation and progression. The multiple …

The advancement of human genomics has revolutionized our understanding of the genetic
architecture of many skeletal diseases, including osteoporosis. However, interpreting results …