The spatiotemporal control of RNA polymerase II (Pol II)-mediated gene transcription is
tightly and intricately regulated. In addition, preservation of the integrity of the DNA template …

Nucleotide excision repair (NER) eliminates various structurally unrelated DNA lesions by a
multiwise'cut and patch'-type reaction. The global genome NER (GG-NER) subpathway …

Cisplatin, oxaliplatin, paclitaxel, vincristine and bortezomib are some of the most effective
drugs successfully employed (alone or in combinations) as first-line treatment for common …

It has been difficult to establish whether we are limited to the heart muscle cells we are born
with or if cardiomyocytes are generated also later in life. We have taken advantage of the …

The skin is comprised of different cell types with different proliferative capacities. Skin aging
occurs with chronological age and upon exposure to extrinsic factors such as photodamage …

Disease-causing repeat instability is an important and unique form of mutation that is linked
to more than 40 neurological, neurodegenerative and neuromuscular disorders. DNA repeat …

The generation of cells in the human body has been difficult to study, and our understanding
of cell turnover is limited. Testing of nuclear weapons resulted in a dramatic global increase …

Deficiency in repair of nuclear and mitochondrial DNA damage has been linked to several
neurodegenerative disorders. Many recent experimental results indicate that the post-mitotic …

Aplastic anaemia is a rare haemopoietic stem-cell disorder that results in pancytopenia and
hypocellular bone marrow. Although most cases are acquired, there are unusual inherited …

Nucleotide excision repair provides an important cellular defense against a large variety of
structurally unrelated DNA alterations. Most of these alterations, if unrepaired, may …