Zinc (Zn) nutritional importance has been known for a long time, but in the last decades its
importance in immune modulation has arisen. This review aims at describing the …

The persistence of heavy metals (HMs) in the environment causes adverse effects to all
living organisms; HMs accumulate along the food chain affecting different levels of biological …

Hepatocellular carcinoma (HCC) is a major cause of cancer‐related death worldwide and
currently has the fastest rising incidence of all cancers. Sorafenib was originally identified as …

Liver cancer is the sixth most frequently diagnosed cancer and the third dominant cause of
cancer death worldwide. Ferroptosis is characterized as an iron-dependent form of …

Zinc is one of the most important metal nutrients for species from all kingdoms, being a key
structural or catalytic component of hundreds of enzymes, crucial for the survival of both …

Metallothioneins (MTs) are small cysteine-rich intracellular proteins with four major isoforms
identified in mammals, designated MT-1 through MT-4. The best known biological functions …

Background Copper (Cu) and zinc (Zn) are essential nutrients and cofactors of enzymatic
reactions with their binding partner. Metallothionein (MT) plays an important role in …

Metals are known for playing essential roles in human physiology. Copper and zinc are
trace elements closely dependent on one another and are involved in cell proliferation …

Abstract Cis-diamminedichloroplatinum (II)(cisplatin) is a widely used metal-based
chemotherapeutic drug for the treatment of cancers. However, intrinsic and acquired drug …

Metal ions are essential for plant growth and development, but in excess, these compounds
can become highly toxic. Plants have adopted numerous ways to maintain metal …