Stem cell therapy for spinal cord injury

L Huang, C Fu, F Xiong, C He, Q Wei - Cell transplantation, 2021 - journals.sagepub.com
Traumatic spinal cord injury (SCI) results in direct and indirect damage to neural tissues,
which results in motor and sensory dysfunction, dystonia, and pathological reflex that …

[HTML][HTML] Mesenchymal stem cells in the treatment of spinal cord injuries: A review

VR Dasari, KK Veeravalli, DH Dinh - World journal of stem cells, 2014 - ncbi.nlm.nih.gov
With technological advances in basic research, the intricate mechanism of secondary
delayed spinal cord injury (SCI) continues to unravel at a rapid pace. However, despite our …

Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice

BJ Cummings, N Uchida, SJ Tamaki… - Proceedings of the …, 2005 - National Acad Sciences
We report that prospectively isolated, human CNS stem cells grown as neurospheres (hCNS-
SCns) survive, migrate, and express differentiation markers for neurons and …

Stem cell therapies for acute spinal cord injury in humans: a review

MC Jin, ZA Medress, TD Azad, VM Doulames… - Neurosurgical …, 2019 - thejns.org
Recent advances in stem cell biology present significant opportunities to advance clinical
applications of stem cell–based therapies for spinal cord injury (SCI). In this review, the …

[HTML][HTML] Tissue engineering strategies for the induction of angiogenesis using biomaterials

S Saberianpour, M Heidarzadeh… - Journal of biological …, 2018 - Springer
Angiogenesis is touted as a fundamental procedure in the regeneration and restoration of
different tissues. The induction of de novo blood vessels seems to be vital to yield a …

Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury

E Syková, A Homola, R Mazanec… - Cell …, 2006 - journals.sagepub.com
Stem cell transplants into spinal cord lesions may help to improve regeneration and spinal
cord function. Clinical studies are necessary for transferring preclinical findings from animal …

Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume

M Vendrame, J Cassady, J Newcomb, T Butler… - Stroke, 2004 - Am Heart Assoc
Background and Purpose—Intravenously delivered human umbilical cord blood cells
(HUCBC) have been previously shown to improve functional recovery of stroked rats. To …

[HTML][HTML] Neuropathology: the foundation for new treatments in spinal cord injury

BA Kakulas - Spinal cord, 2004 - nature.com
The first step essential in the search for a cure of human spinal cord injury (SCI) is to
appreciate the complexity of the disorder. In this regard, it is not only the loss of ambulation …

Recovery of function following grafting of human bone marrow-derived stromal cells into the injured spinal cord

BT Himes, B Neuhuber, C Coleman… - … and neural repair, 2006 - journals.sagepub.com
This study evaluates functional recovery after transplanting human bone marrow-derived
stromal cells (BMSCs) into contusion models of spinal cord injury (SCI). The authors used a …

Anti-inflammatory effects of human cord blood cells in a rat model of stroke

M Vendrame, C Gemma, DD Mesquita… - Stem cells and …, 2005 - liebertpub.com
When human umbilical cord blood cells (HUCBCs) are administered intravenously after a
middle cerebral artery occlusion, they reliably produce behavioral and anatomical recovery …