The recent impressive clinical responses to antibody-based immunotherapy have prompted
the identification of clinically relevant tumor antigens that can serve as targets in solid …

Targeting the anti-tumor immune response via the B7 family of immune-regulatory
checkpoint proteins has revolutionized cancer treatment and resulted in punctuated …

Background Small cell lung cancer (SCLC) is an aggressive lung cancer subtype that is
associated with high recurrence and poor prognosis. Due to lack of potential drug targets …

At present, the incidence of cancer is becoming more and more common, but its treatment
has always been a problem. Although a small number of cancers can be treated, the …

Medulloblastoma (MB) is the most common malignant central nervous system tumor in
pediatric patients. Mainstay of therapy remains surgical resection followed by craniospinal …

Abstract B7-H3 (CD276 molecule) is an immune checkpoint from the B7 family of molecules
that acts more as a co-inhibitory molecule to promote tumor progression. It is abnormally …

Background Radiation is currently used to be a mainstay of salvage therapy for
nasopharyngeal carcinoma (NPC), however, development of radioresistance largely limits …

Objective Exosomes, membranous nanovesicles, naturally bringing proteins, mRNAs, and
microRNAs (miRNAs), play crucial roles in tumor pathogenesis. This study was to …

Purpose Medulloblastomas (MB) are highly malignant brain tumors that predominantly occur
in young infants. Immunotherapy to boost the immune system is emerging as a novel …

Simple Summary Medulloblastoma (MB) is a primary brain tumor and is one of the most
prevalent neoplasms in the pediatric age group, with a median age of diagnosis of six years …