Poly (ADP-ribose) polymerase-1 (PARP-1) is a member of the PARP enzyme family
consisting of PARP-1 and several recently identified novel poly (ADP-ribosylating) enzymes …

Homeostatic regulation of cardiomyocytes plays a crucial role in maintaining the normal
physiological activity of cardiac tissue. Severe cardiotoxicity results in cardiac diseases …

Highly active antiretroviral therapy (HAART) regimes based on nucleoside reverse
transcriptase inhibitors (NRTIs) have revolutionized the treatment of AIDS in recent years …

Mitochondria play a central role in energy metabolism within the cell. Mitochondrial
dysfunctions lead to various neurodegenerative disorders and to the so-called …

Scope Binge consumption of alcohol is an alarming global health problem. Acute ethanol
intoxication is characterized by hepatic inflammation and oxidative stress, which could be …

To elucidate the potential role of mitochondria in Taxol-induced cytotoxicity, we studied its
direct mitochondrial effects. In Percoll-gradient purified liver mitochondria, Taxol induced …

In this article we present the synthesis, characterization, and in vitro biological and
biochemical activities of new chalcogenozidovudine derivatives as antioxidant (inhibition of …

Mitochondrial toxicity can result from antiviral nucleotide analog therapy used to control
human immunodeficiency virus type 1 infection. We evaluated the ability of such analogs to …

Atrial fibrillation (AF) is the most common cause of arrhythmia and is an aging-related
disease encountered in clinical practice. The electrophysiological remolding with Ca2+ …

Nucleoside reverse transcriptase inhibitors (NRTIs) in combinations with other antiretrovirals
(highly active antiretroviral therapy, HAART) are the cornerstones of AIDS therapy, turning …