[HTML][HTML] Role of JAK/STAT in interstitial lung diseases; molecular and cellular mechanisms
P Montero, J Milara, I Roger, J Cortijo - International journal of molecular …, 2021 - mdpi.com
Interstitial lung diseases (ILDs) comprise different fibrotic lung disorders characterized by
cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway …
cellular proliferation, interstitial inflammation, and fibrosis. The JAK/STAT molecular pathway …
[HTML][HTML] Anti-rheumatoid drugs advancements: New insights into the molecular treatment of rheumatoid arthritis
RB Mrid, N Bouchmaa, H Ainani, R El Fatimy… - Biomedicine & …, 2022 - Elsevier
Rheumatoid arthritis (RA) is one of more than 100 types of arthritis. This chronic autoimmune
disorder affects the lining of synovial joints in about 0.5% of people and may induce severe …
disorder affects the lining of synovial joints in about 0.5% of people and may induce severe …
[HTML][HTML] Adverse events associated with JAK inhibitors in 126,815 reports from the WHO pharmacovigilance database
L Hoisnard, B Lebrun-Vignes, S Maury, M Mahevas… - Scientific Reports, 2022 - nature.com
Increasing number of Janus kinase (JAK) inhibitors have been approved for chronic
haematopoietic neoplasms and inflammatory/autoimmune diseases. We aimed to assess …
haematopoietic neoplasms and inflammatory/autoimmune diseases. We aimed to assess …
The JAK–STAT pathway: an emerging target for cardiovascular disease in rheumatoid arthritis and myeloproliferative neoplasms
C Baldini, FR Moriconi, S Galimberti… - European Heart …, 2021 - academic.oup.com
Inflammation contributes centrally to cardiovascular diseases, and anti-inflammatory
treatments can reduce cardiovascular events. The JAK–STAT pathway is an emerging target …
treatments can reduce cardiovascular events. The JAK–STAT pathway is an emerging target …
Type I interferons in the pathogenesis and treatment of autoimmune diseases
J Jiang, M Zhao, C Chang, H Wu, Q Lu - Clinical reviews in allergy & …, 2020 - Springer
Abstract Type I interferons (IFN-Is) are a very important group of cytokines that are produced
by innate immune cells but also act on adaptive immune cells. IFN-Is possess antiviral …
by innate immune cells but also act on adaptive immune cells. IFN-Is possess antiviral …
[HTML][HTML] Where are we moving in the classification of idiopathic inflammatory myopathies?
Where are we moving in the classification of idiopathic infl... : Current Opinion in Neurology
Where are we moving in the classification of idiopathic inflammatory myopathies? : Current …
Where are we moving in the classification of idiopathic inflammatory myopathies? : Current …
Combined anti-fibrotic and anti-inflammatory properties of JAK-inhibitors on macrophages in vitro and in vivo: perspectives for scleroderma-associated interstitial lung …
A Lescoat, M Lelong, M Jeljeli, C Piquet-Pellorce… - Biochemical …, 2020 - Elsevier
Janus kinase (JAK) inhibitors (also termed Jakinibs) constitute a family of small drugs that
target various isoforms of JAKs (JAK1, JAK2, JAK3 and/or tyrosine kinase 2 (Tyk2)). They …
target various isoforms of JAKs (JAK1, JAK2, JAK3 and/or tyrosine kinase 2 (Tyk2)). They …
[HTML][HTML] New approaches for the treatment of chronic graft-versus-host disease: current status and future directions
Chronic graft-versus-host disease (cGvHD) is a severe complication of allogeneic
hematopoietic stem cell transplantation that affects various organs leading to a reduced …
hematopoietic stem cell transplantation that affects various organs leading to a reduced …
[HTML][HTML] Anti-inflammatory mechanisms of dietary flavones: tapping into nature to control chronic inflammation in obesity and cancer
A Kariagina, AI Doseff - International Journal of Molecular Sciences, 2022 - mdpi.com
Flavones are natural phytochemicals broadly distributed in our diet. Their anti-inflammatory
properties provide unique opportunities to control the innate immune system and …
properties provide unique opportunities to control the innate immune system and …
The infection risks of JAK inhibition
MA Adas, E Alveyn, E Cook, M Dey… - Expert Review of …, 2022 - Taylor & Francis
ABSTRACT Introduction Janus Kinase inhibitors (JAKi) have shown to be highly effective in
the treatment of immune-mediated inflammatory diseases. As with all immunomodulatory …
the treatment of immune-mediated inflammatory diseases. As with all immunomodulatory …