Membrane homeostasis beyond fluidity: control of membrane compressibility
Biomembranes are complex materials composed of lipids and proteins that
compartmentalize biochemistry. They are actively remodeled in response to physical and …
compartmentalize biochemistry. They are actively remodeled in response to physical and …
Balancing energy and protein homeostasis at ER-mitochondria contact sites
The endoplasmic reticulum (ER) is the largest organelle of the cell and participates in
multiple essential functions, including the production of secretory proteins, lipid synthesis …
multiple essential functions, including the production of secretory proteins, lipid synthesis …
Regulation of lipid saturation without sensing membrane fluidity
Cells maintain membrane fluidity by regulating lipid saturation, but the molecular
mechanisms of this homeoviscous adaptation remain poorly understood. We have …
mechanisms of this homeoviscous adaptation remain poorly understood. We have …
Principles of membrane adaptation revealed through environmentally induced bacterial lipidome remodeling
Cells, from microbes to mammals, adapt their membrane lipid composition in response to
environmental changes to maintain optimal properties. Global patterns of lipidome …
environmental changes to maintain optimal properties. Global patterns of lipidome …
[HTML][HTML] Emerging principles of selective ER autophagy
S Wilkinson - Journal of molecular biology, 2020 - Elsevier
The endoplasmic reticulum (ER) is a fundamental organelle in cellular metabolism and
signal transduction. It is subject to complex, dynamic sculpting of morphology and …
signal transduction. It is subject to complex, dynamic sculpting of morphology and …
The unfolded protein response as a guardian of the secretory pathway
T Radanović, R Ernst - Cells, 2021 - mdpi.com
The endoplasmic reticulum (ER) is the major site of membrane biogenesis in most
eukaryotic cells. As the entry point to the secretory pathway, it handles more than 10,000 …
eukaryotic cells. As the entry point to the secretory pathway, it handles more than 10,000 …
Beyond fluidity: the role of lipid unsaturation in membrane function
T Harayama, B Antonny - Cold Spring Harbor …, 2023 - cshperspectives.cshlp.org
The number of double bonds in the acyl chains of membrane lipids varies tremendously at
all scales of life, from the organism level to the subcellular level, where differences in lipid …
all scales of life, from the organism level to the subcellular level, where differences in lipid …
Unique amphipathic α helix drives membrane insertion and enzymatic activity of ATG3
Autophagosome biogenesis requires a localized perturbation of lipid membrane dynamics
and a unique protein-lipid conjugate. Autophagy-related (ATG) proteins catalyze this …
and a unique protein-lipid conjugate. Autophagy-related (ATG) proteins catalyze this …
The more the merrier: effects of macromolecular crowding on the structure and dynamics of biological membranes
M Löwe, M Kalacheva, AJ Boersma… - The FEBS …, 2020 - Wiley Online Library
Proteins are essential and abundant components of cellular membranes. Being densely
packed within the limited surface area, proteins fulfil essential tasks for life, which include …
packed within the limited surface area, proteins fulfil essential tasks for life, which include …
Endoplasmic reticulum membrane homeostasis and the unfolded protein response
The endoplasmic reticulum (ER) is the key organelle for membrane biogenesis. Most lipids
are synthesized in the ER, and most membrane proteins are first inserted into the ER …
are synthesized in the ER, and most membrane proteins are first inserted into the ER …