The substantial investments in human genetics and genomics made over the past three
decades were anticipated to result in many innovative therapies. Here we investigate the …

Genome-wide association studies (GWAS) have provided insights into the genetic basis of
complex diseases. In the next step, integrative multi-omics approaches can characterize …

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

Osteoarthritis is the most common musculoskeletal disease and the leading cause of
disability globally. Here, we performed a genome-wide association study for osteoarthritis …

Osteoarthritis is a common complex disease imposing a large public-health burden. Here,
we performed a genome-wide association study for osteoarthritis, using data across 16.5 …

Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …

Recent research in the field of osteoarthritis (OA) has focused on understanding the
underlying molecular and clinical phenotypes of the disease. This narrative review article …

Objective Osteoarthritis (OA) is the most prevalent joint disease. As disease-modifying
therapies are not available, novel therapeutic targets need to be discovered and prioritized …

We aimed to identify markers in blood (serum) to predict clinically relevant knee
osteoarthritis (OA) progression defined as the combination of both joint structure and pain …

Senescent cells (SnCs) are associated with age-related pathologies. Osteoarthritis is a
chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its …