Asthma and chronic obstructive pulmonary disease (COPD) represent two classes of chronic
obstructive lung disorders that may share some similar immunologic mechanisms of …

Animal models of asthma are a tool that allows studies to be conducted in the setting of an
intact immune and respiratory system. These models have highlighted the importance of T …

The development of a tractable small animal model faithfully reproducing human
coronavirus disease 2019 pathogenesis would arguably meet a pressing need in …

The identification of novel helper T (Th) cell subsets, ie, IL-17-producing Th cells (Th17 cells)
and regulatory T cells (Treg cells), provided new insight into our understanding of the …

ABSTRACT Transmembrane member 16A (TMEM16A) is the Ca2+‐activated chloride
channel in airways and intestine. It has been associated with goblet cell metaplasia, as …

Airway disease currently causes most of the morbidity and mortality in patients with cystic
fibrosis (CF). However, understanding the pathogenesis of CF lung disease and developing …

There is no currently licensed vaccine for respiratory syncytial virus (RSV) despite being the
leading cause of lower respiratory tract infections in children. Children previously immunized …

Background In humans the prevalence of asthma is higher among females than among
males after puberty. The reason for this phenomenon is not clear. Objective We tested the …

Studies in animal models form the basis for much of our current understanding of the
pathophysiology of asthma, and are central to the preclinical development of drug therapies …

Asthma is a common lower-airway inflammatory disease in cats thought to be allergic in
origin. 1 Aeroallergen-induced stimulation of a T-helper 2 response leads to elaboration of a …