Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity,
where every olfactory neuron expresses one out of~ 2000 OR alleles in the mouse genome …

Comparative genomics has revealed the rapid expansion of multiple gene families involved
in immunity. Members within each gene family often evolved distinct roles in immunity …

The family of trace amine-associated receptors (TAARs) is distantly related to G protein-
coupled biogenic aminergic receptors. TAARs are found in the brain as well as in the …

Humans use a family of more than 400 olfactory receptors (ORs) to detect odorants.
However, deorphanization of ORs is a critical issue because the functional properties of …

This Review elucidates the regulatory principles of random monoallelic expression by
focusing on two well-studied examples: the X-chromosome inactivation regulator Xist and …

The mammalian sense of smell relies upon a vast array of receptor proteins to detect
odorant compounds present in the environment. The proper deployment of these receptor …

Olfactory sensory neurons express a large family of odorant receptors (ORs) and a small
family of trace amine-associated receptors (TAARs). While both families are subject to so …

Mitotically stable random monoallelic gene expression (RME) is documented for a small
percentage of autosomal genes. We developed an in vivo genetic model to study the role of …

Parkinson's disease (PD) is characterized not only by motor symptoms but also by non-
motor dysfunctions, such as olfactory impairment; the cause is not fully understood. Our …

In the mouse, more than 1,100 odorant receptors (ORs) are expressed in a monogenic and
monoallelic fashion, referred to as singular gene expression. Using a 21bp singular-choice …