The links between the gut microbiome, aging, modern lifestyle and Alzheimer's disease

S Askarova, B Umbayev, AR Masoud… - Frontiers in cellular …, 2020 - frontiersin.org
Gut microbiome is a community of microorganisms in the gastrointestinal tract. These
bacteria have a tremendous impact on the human physiology in healthy individuals and …

A review of the preclinical and clinical studies on the role of the gut microbiome in aging and neurodegenerative diseases and its modulation

HM Hashim, S Makpol - Frontiers in cellular neuroscience, 2022 - frontiersin.org
As the world population ages, the burden of age-related health problems grows, creating a
greater demand for new novel interventions for healthy aging. Advancing aging is related to …

Fusobacterium nucleatum secretes amyloid‐like FadA to enhance pathogenicity

Q Meng, Q Gao, S Mehrazarin… - EMBO …, 2021 - embopress.org
Fusobacterium nucleatum (Fn) is a Gram‐negative oral commensal, prevalent in various
human diseases. It is unknown how this common commensal converts to a rampant …

Carbon dot-based therapeutics for combating drug-resistant bacteria and biofilm infections in food preservation

F Cui, Y Ning, D Wang, J Li, X Li, T Li - Critical Reviews in Food …, 2024 - Taylor & Francis
Drug-resistant bacteria are caused by antibiotic abuse and/or biofilm formation and have
become a threat to the food industry. Carbon dot (CD)-based nanomaterials are a very …

Repertoire of the Bacillus thuringiensis Virulence Factors Unrelated to Major Classes of Protein Toxins and Its Role in Specificity of Host-Pathogen Interactions

YV Malovichko, AA Nizhnikov, KS Antonets - Toxins, 2019 - mdpi.com
Bacillus thuringiensis (Bt) is a Gram-positive soil bacteria that infects invertebrates,
predominantly of Arthropoda phylum. Due to its immense host range Bt has become a …

Iron dysregulation and inflammagens related to oral and gut health are central to the development of Parkinson's disease

MJ Vuuren, TA Nell, JA Carr, DB Kell, E Pretorius - Biomolecules, 2020 - mdpi.com
Neuronal lesions in Parkinson's disease (PD) are commonly associated with α-synuclein (α-
Syn)-induced cell damage that are present both in the central and peripheral nervous …

Bacterial amyloid curli associated gut epithelial neuroendocrine activation predominantly observed in Alzheimer's disease mice with central amyloid-β pathology

TK Das, MP Blasco-Conesa, J Korf… - Journal of …, 2022 - content.iospress.com
Background: Substantial evidence from recent research suggests an influential and
underappreciated force in Alzheimer's disease (AD) pathogenesis: the pathological signals …

CsgA gatekeeper residues control nucleation but not stability of functional amyloid

WP Olsen, G Courtade, S Peña‐Díaz… - Protein …, 2024 - Wiley Online Library
Functional amyloids, beneficial to the organism producing them, are found throughout life,
from bacteria to humans. While disease‐related amyloids form by uncontrolled aggregation …

An inclusive study of recent advancements in Alzheimer's disease: A comprehensive review

S Singh, M Mahajan, D Kumar, K Singh, M Chowdhary - Neuropeptides, 2023 - Elsevier
Alzheimer's disease (AD) has remained elusive in revealing its pathophysiology and
mechanism of development. In this review paper, we attempt to highlight several theories …

CRISPRi-mediated suppression of E. coli Nissle 1917 virulence factors: A strategy for creating an engineered probiotic using csgD gene suppression

MW Azam, AU Khan - Frontiers in Nutrition, 2022 - frontiersin.org
Background Biofilm formation is a complex phenomenon, and it is the causative agent of
several human infections. Bacterial amyloids are involved in biofilm formation leading to …