Immune system aging is characterized by the paradox of immunosenescence (insufficiency)
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …

The thymus is an organ that is critically important to the immune system, which serves as the
body's defense mechanism, providing surveillance and protection against diverse …

Intrathymic T cell development is a complex process that depends upon continuous
guidance from thymus stromal cell microenvironments. The thymic epithelium within the …

Age-related regression of the thymus is associated with a decline in naïve T cell output. This
is thought to contribute to the reduction in T cell diversity seen in older individuals and linked …

Thymic epithelial cell differentiation, growth and function depend on the expression of the
transcription factor Foxn1; however, its target genes have never been physically identified …

Age-related thymic involution is characterized by a progressive regression in thymus size
and a diminishment of thymic structure. A decrease in thymic compartments leads to the …

Thymic epithelial cells (TECs) are critical for T cell development and self-tolerance but are
gradually lost with age. The existence of thymic epithelial progenitors (TEPCs) in the …

Development of the primary T‐cell repertoire takes place in the thymus. The linked
processes of T‐cell differentiation and T‐cell repertoire selection each depend on …

The forkhead transcription factor Foxn1 is indispensable for thymus development, but the
mechanisms by which it mediates thymic epithelial cell (TEC) development are poorly …

The thymus is not only extremely sensitive to damage but also has a remarkable ability to
repair itself. However, the mechanisms underlying this endogenous regeneration remain …