The extended granin family: structure, function, and biomedical implications

A Bartolomucci, R Possenti, SK Mahata… - Endocrine …, 2011 - academic.oup.com
The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II
and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) …

[HTML][HTML] The dynamic nature of exocytosis from large secretory vesicles. A view from electrochemistry and imaging

R Borges, C Gu, JD Machado, AG Ewing - Cell Calcium, 2023 - Elsevier
In this brief review, we discuss the factors that modulate the quantum size and the kinetics of
exocytosis. We also discuss the determinants which motivate the type of exocytosis from the …

Cerebrospinal fluid proteomics implicates the granin family in Parkinson's disease

MS Rotunno, M Lane, W Zhang, P Wolf, P Oliva… - Scientific reports, 2020 - nature.com
Parkinson's disease, the most common age-related movement disorder, is a progressive
neurodegenerative disease with unclear etiology. Better understanding of the underlying …

Carbon-fiber nanoelectrodes for real-time discrimination of vesicle cargo in the native cellular environment

JG Roberts, EC Mitchell, LE Dunaway, GS McCarty… - ACS …, 2020 - ACS Publications
Carbon-fiber microelectrodes have proven to be an indispensable tool for monitoring
exocytosis events using amperometry. When positioned adjacent to a cell, a traditional …

Targeted multiple reaction monitoring analysis of CSF identifies UCHL1 and GPNMB as candidate biomarkers for ALS

S Zhu, A Wuolikainen, J Wu, A Öhman… - Journal of Molecular …, 2019 - Springer
The neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and Parkinson's
disease (PD) share some common molecular deficits including disruption of protein …

Tuning the Size of Large Dense‐Core Vesicles and Quantal Neurotransmitter Release via Secretogranin II Liquid–Liquid Phase Separation

Z Lin, Y Li, Y Hang, C Wang, B Liu, J Li, L Yin… - Advanced …, 2022 - Wiley Online Library
Large dense‐core vesicles (LDCVs) are larger in volume than synaptic vesicles, and are
filled with multiple neuropeptides, hormones, and neurotransmitters that participate in …

Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells

SC Bearrows, CJ Bauchle, MK Becker… - Journal of cell …, 2019 - journals.biologists.com
Chromogranin B (CgB, also known as CHGB) is abundantly expressed in dense core
secretory granules of multiple endocrine tissues and has been suggested to regulate …

ATP: The crucial component of secretory vesicles

J Estévez-Herrera, N Domínguez… - Proceedings of the …, 2016 - National Acad Sciences
The colligative properties of ATP and catecholamines demonstrated in vitro are thought to
be responsible for the extraordinary accumulation of solutes inside chromaffin cell secretory …

[图书][B] Nanoelectrochemistry

MV Mirkin, S Amemiya - 2015 - api.taylorfrancis.com
The number of scientific disciplines whose names begin with the prefix nano has grown
dramatically since the launch of the National Nanotechnology Initiative in 2000. Some of …

Astrocyte Transcriptome from the Mecp2308-Truncated Mouse Model of Rett Syndrome

C Delépine, J Nectoux, F Letourneur, V Baud… - Neuromolecular …, 2015 - Springer
Mutations in the gene encoding the transcriptional modulator methyl-CpG binding protein 2
(MeCP2) are responsible for the neurodevelopmental disorder Rett syndrome which is one …