Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …

Antigenic peptide-loaded MHC class II molecules (peptide–MHC class II) are constitutively
expressed on the surface of professional antigen-presenting cells (APCs), including …

Phagocytosis, the regulated uptake of large particles (> 0.5 μm in diameter), is essential for
tissue homeostasis and is also an early, critical component of the innate immune response …

Long known as digestive organelles, lysosomes have now emerged as multifaceted centers
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …

Lysosomes play important roles in cellular degradation to maintain cell homeostasis. In
order to understand whether and how lysosomes alter with age and contribute to lifespan …

Phagocytes, particularly dendritic cells (DCs), generate peptide-major histocompatibility
complex (MHC) I complexes from antigens they have collected from cells in tissues and …

As a population, dendritic cells (DC s) appear to be the best cross‐presenters of internalized
antigens on major histocompatibility complex class I molecules in the mouse. To do this, DC …

Activation of cells in the adaptive immune system is a highly orchestrated process dictated
by multiples cues from the innate immune system. Although the fundamental principles of …

Despite advances in critical care medicine, infection remains a significant problem that
continues to be complicated with the challenge of antibiotic resistance …

Lysosomes are the terminal degradative compartment of autophagy, endocytosis and
phagocytosis. What once was viewed as a simple acidic organelle in charge of …