Due to the pharmacological activities of quinazoline and quinazolinone scaffolds, it has
aroused great interest in medicinal chemists for the development of new drugs or drug …

Abstract The 1, 3, 4‐oxadiazole nucleus is a biologically imperative scaffold possesses
numerous biological activities. The broad and potent activity of 1, 3, 4‐oxadiazole and their …

Quinazolinone and quinazoline have been shown different pharmacological activities,
namely anticancer, anti-inflammatory, anti-hyperlipidemia, analgesic, antihypertensive, and …

Background: Cancer is the first or second leading cause of premature death in 134 of 183
countries in the world. 1, 3, 4-Oxadiazoles are five membered heterocyclic rings containing …

The evaluation of antioxidant compounds that counteract the mutagenic effects caused by
the direct action of reactive oxygen species on DNA molecule is of considerable interest …

One of the goals of green chemistry is to use environmentally friendly solvents or remove
and reduce the volume of harmful spent solvents. In this study, a novel process for the …

Abstract Twenty 2, 3-disubstituted quinazolin-4 (3H)-one derivatives 1–20 were successfully
synthesized in moderate to good yields (25–82%). Their syntheses were based on a one pot …

Background and purpose: Oxadiazole-derived compounds have been shown to have a wide
range of pharmacological activities. 2, 5-Disubstituted 1, 3, 4-oxadiazole derivatives have …

This report presents the design and synthesis of quinazolinone-based derivatives as
promising SARS-CoV-2 3CL protease inhibitors. Two novel series, namely, febrifugine …

Eleven 3-amino-2-methyl-quinazolin-4 (3 H)-ones have been synthesized, in good to
excellent yields, via their corresponding benzoxazinones using an efficient tandem …