Probabilistic genotyping software: an overview
The interpretation of mixed profiles from DNA evidentiary material is one of the more
challenging duties of the forensic scientist. Traditionally, analysts have used a “binary” …
challenging duties of the forensic scientist. Traditionally, analysts have used a “binary” …
Genotyping and interpretation of STR-DNA: low-template, mixtures and database matches—twenty years of research and development
Abstract The introduction of Short Tandem Repeat (STR) DNA was a revolution within a
revolution that transformed forensic DNA profiling into a tool that could be used, for the first …
revolution that transformed forensic DNA profiling into a tool that could be used, for the first …
DNA commission of the International Society of Forensic Genetics: recommendations on the evaluation of STR typing results that may include drop-out and/or drop-in …
DNA profiling of biological material from scenes of crimes is often complicated because the
amount of DNA is limited and the quality of the DNA may be compromised. Furthermore, the …
amount of DNA is limited and the quality of the DNA may be compromised. Furthermore, the …
Analysis of forensic DNA mixtures with artefacts
RG Cowell, T Graversen, SL Lauritzen… - Journal of the Royal …, 2015 - academic.oup.com
DNA is now routinely used in criminal investigations and court cases, although DNA
samples taken at crime scenes are of varying quality and therefore present challenging …
samples taken at crime scenes are of varying quality and therefore present challenging …
Exploratory data analysis for the interpretation of low template DNA mixtures
The interpretation of DNA mixtures has proven to be a complex problem in forensic genetics.
In particular, low template DNA samples, where alleles can be missing (allele drop-out), or …
In particular, low template DNA samples, where alleles can be missing (allele drop-out), or …
Evaluation of mixed-source, low-template DNA profiles in forensic science
DJ Balding - Proceedings of the national academy of …, 2013 - National Acad Sciences
Enhancements in sensitivity now allow DNA profiles to be obtained from only tens of
picograms of DNA, corresponding to a few cells, even for samples subject to degradation …
picograms of DNA, corresponding to a few cells, even for samples subject to degradation …
Statistical evaluation of forensic DNA profile evidence
CD Steele, DJ Balding - Annual Review of Statistics and Its …, 2014 - annualreviews.org
The evaluation of weight of evidence for forensic DNA profiles has been a subject of
controversy since their introduction over 20 years ago. Substantial progress has been made …
controversy since their introduction over 20 years ago. Substantial progress has been made …
Forensic genetic SNP typing of low-template DNA and highly degraded DNA from crime case samples
C Børsting, HS Mogensen, N Morling - Forensic Science International …, 2013 - Elsevier
Heterozygote imbalances leading to allele drop-outs and disproportionally large stutters
leading to allele drop-ins are known stochastic phenomena related to STR typing of low …
leading to allele drop-ins are known stochastic phenomena related to STR typing of low …
Validating multiplexes for use in conjunction with modern interpretation strategies
In response to requests from the forensic community, commercial companies are generating
larger, more sensitive, and more discriminating STR multiplexes. These multiplexes are now …
larger, more sensitive, and more discriminating STR multiplexes. These multiplexes are now …
Validation of a DNA mixture statistics tool incorporating allelic drop-out and drop-in
AA Mitchell, J Tamariz, K O'Connell, N Ducasse… - Forensic Science …, 2012 - Elsevier
DNA mixture analysis is a current topic of discussion in the forensics literature. Of particular
interest is how to approach mixtures where allelic drop-out and/or drop-in may have …
interest is how to approach mixtures where allelic drop-out and/or drop-in may have …