The DNA methylation landscape in cancer
As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …
plays an essential role in normal development and cellular biology. Global alterations to the …
The epigenetics of epithelial-mesenchymal plasticity in cancer
WL Tam, RA Weinberg - Nature medicine, 2013 - nature.com
During the course of malignant cancer progression, neoplastic cells undergo dynamic and
reversible transitions between multiple phenotypic states, the extremes of which are defined …
reversible transitions between multiple phenotypic states, the extremes of which are defined …
The DNA methylation landscape of advanced prostate cancer
Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …
methylation landscape of metastatic cancer has never been defined. Through whole …
Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling
Background In recent years the Illumina HumanMethylation450 (HM450) BeadChip has
provided a user-friendly platform to profile DNA methylation in human samples. However …
provided a user-friendly platform to profile DNA methylation in human samples. However …
A decade of exploring the cancer epigenome—biological and translational implications
The past decade has highlighted the central role of epigenetic processes in cancer
causation, progression and treatment. Next-generation sequencing is providing a window …
causation, progression and treatment. Next-generation sequencing is providing a window …
[HTML][HTML] Interplay between the cancer genome and epigenome
Cancer arises as a consequence of cumulative disruptions to cellular growth control with
Darwinian selection for those heritable changes that provide the greatest clonal advantage …
Darwinian selection for those heritable changes that provide the greatest clonal advantage …
Three-dimensional disorganization of the cancer genome occurs coincident with long-range genetic and epigenetic alterations
A three-dimensional chromatin state underpins the structural and functional basis of the
genome by bringing regulatory elements and genes into close spatial proximity to ensure …
genome by bringing regulatory elements and genes into close spatial proximity to ensure …
Charting histone modifications and the functional organization of mammalian genomes
VW Zhou, A Goren, BE Bernstein - Nature Reviews Genetics, 2011 - nature.com
A succession of technological advances over the past decade have enabled researchers to
chart maps of histone modifications and related chromatin structures with increasing …
chart maps of histone modifications and related chromatin structures with increasing …
De novo identification of differentially methylated regions in the human genome
Background The identification and characterisation of differentially methylated regions
(DMRs) between phenotypes in the human genome is of prime interest in epigenetics. We …
(DMRs) between phenotypes in the human genome is of prime interest in epigenetics. We …
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains
Extensive changes in DNA methylation are common in cancer and may contribute to
oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale …
oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale …