The indole ring system is present in many natural products, pharmaceuticals,
agrochemicals, and other compounds of importance. 1–8 The indole unit forms the basis for …

Hydrolysis of glucobrassicin by plant or bacterial myrosinase produces multiple indoles
predominantly indole-3-carbinol (I3C). I3C and its major in vivo product, 3, 3' …

Pancreatic cancer is the fourth most common cause of cancer death in the United States,
and the aggressiveness of pancreatic cancer is in part due to its intrinsic and extrinsic drug …

The aggressive course of pancreatic cancer is believed to reflect its unusually invasive and
metastatic nature, which is associated with epidermal growth factor receptor (EGFR) …

An inverse correlation between vegetable consumption and the incidence of cancer has
long been described. This protective effect is stronger when cruciferous vegetables are …

Pancreatic cancer is the fourth leading cause of cancer related death in the US and exhibits
aggressive features with short survival rate and high mortality. Therefore, it is important to …

Emerging evidence provide credible support in favor of the potential role of bioactive
products derived from ingesting cruciferous vegetables such as broccoli, brussel sprouts …

MicroRNA (miRNA) are small noncoding RNA molecules that are involved in post-
transcriptional gene silencing. Alterations in miRNA expression are observed in and may …

Diet is a modifiable factor associated with the risk of several cancers, with convincing
evidence showing a link between diet and breast cancer. The role of bioactive compounds …

We have completed a phase I trial in women of the proposed chemopreventive natural
product indole-3-carbinol (I3C). Women received oral doses of 400, 600, 800, 1,000, and …