The cardiac extracellular matrix (ECM) is a complex architectural network consisting of
structural and nonstructural proteins, creating strength and plasticity. The nonstructural …

The endothelial glycocalyx is a negatively charged, carbohydrate-rich structure that arises
from the luminal surface of the vascular endothelium and is comprised of proteoglycans …

Skeletal muscle aging results in a gradual loss of skeletal muscle mass, skeletal muscle
function and regenerative capacity, which can lead to sarcopenia and increased mortality …

Ischemic heart disease is a leading cause of mortality due to irreversible damage to cardiac
muscle. Inspired by the post-ischemic microenvironment, we devised an extracellular matrix …

Abstract The 1, 9-dimethylmethylene blue (DMMB) assay is widely used to quantify sulfated
glycosaminoglycan (sGAG) contents of engineered tissues, culture media, tissue samples …

Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and prion diseases, are
directly linked to the formation and accumulation of protein aggregates in the brain. These …

The biological properties of Heparan sulfate (HS) polysaccharides essentially rely on their
ability to bind and modulate a multitude of protein ligands. These interactions involve …

Background: Heart failure is a leading cause of mortality and morbidity, and the search for
novel therapeutic approaches continues. In the monogenic disease mucopolysaccharidosis …

Osteoarthritis (OA) is a common degenerative joint disease, characterized by cartilage loss
and subchondral bone remodeling in response to abnormal mechanical load. Heparan …

Skeletal dysplasia with multiple dislocations are severe disorders characterized by
dislocations of large joints and short stature. The majority of them have been linked to …