Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …

Blood vessels respond to changes in mechanical load from circulating blood in the form of
shear stress and mechanical strain as the result of heart propulsions by changes in …

We report a lung-on-a-chip array that mimics the pulmonary parenchymal environment,
including the thin alveolar barrier and the three-dimensional cyclic strain induced by …

The proportion of patients receiving protective ventilatory strategies remains modest. If
efforts to minimize the iatrogenic consequences of mechanical ventilation are to succeed …

Overdistention of lung tissue during mechanical ventilation may be one of the factors that
initiates ventilator-induced lung injury (VILI). We hypothesized that cyclic mechanical stretch …

Oxidative stress is considered one of the early underlying contributors of acute lung injury
(ALI) and ventilator-induced lung injury (VILI). DJ-1, also known as PARK7, has a well …

Of the antioxidant/prooxidant mechanisms mediating the regulation of inflammatory
mediators, particularly cytokines, oxidative stress-related pathways remain a cornerstone. It …

Epithelial cells of the lung are located at the interface between the environment and the
organism and serve many important functions including barrier protection, fluid balance …

Objective: Mechanical ventilation (MV) has long been used as a life-sustaining approach for
several decades. However, researchers realized that MV not only brings benefits to patients …

Mechanical ventilation generates biophysical forces, including high transmural pressures,
which exacerbate lung inflammation. This study sought to determine whether microRNAs …