The transcription factor Snai2, encoded by the SNAI2 gene, is an evolutionarily conserved
C2H2 zinc finger protein that orchestrates biological processes critical to tissue development …

Significance: Pulmonary arterial hypertension (PAH) is a progressive disease of the lung
vasculature characterized by the proliferation of all vascular wall cell types, including …

Pulmonary hypertension (PH) is a chronic and fatal disease, for which new therapeutic
drugs and approaches are needed urgently. Baicalein and baicalin, the active compounds …

Background Vascular smooth muscle cell (VSMC) phenotypic switching contributes to
VSMC proliferation and migration in atherosclerosis (AS). Nevertheless, the regulatory …

Pulmonary vascular remodeling is an angiogenic-related process involving changes in
smooth muscle cell (SMC) homeostasis, which is frequently observed in chronic obstructive …

Hutchinson-Gilford progeria syndrome is a premature aging disease caused by LMNA gene
mutation and the production of a truncated prelamin A protein “progerin” that elicits cellular …

Blood vessel organoids (BVOs) derived from human pluripotent stem cells have emerged as
a novel system to understand human vascular development, model disorders, and develop …

Background Heart attacks and stroke often result from occlusive thrombi following the
rupture of vulnerable atherosclerotic plaques. Vascular smooth muscle cells (VSMC s) play …

Nanotechnology is a very promising technological tool to combat health problems
associated with the loss of effectiveness of currently used antibiotics. Previously, we …

Simple Summary Glioblastoma multiforme is the most aggressive form of brain tumor and is
still incurable. These neoplasms are particularly difficult to treat efficiently because of their …