Generation of nanoscopic membrane curvature for membrane trafficking
MM Kozlov, JW Taraska - Nature reviews Molecular cell biology, 2023 - nature.com
Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …
Peptide design principles for antimicrobial applications
The increased incidence of bacterial resistance to available antibiotics represents a major
global health problem and highlights the need for novel anti-infective therapies …
global health problem and highlights the need for novel anti-infective therapies …
When physics takes over: BAR proteins and membrane curvature
Cell membranes become highly curved during membrane trafficking, cytokinesis, infection,
immune response, or cell motion. Bin/amphiphysin/Rvs (BAR) domain proteins with their …
immune response, or cell motion. Bin/amphiphysin/Rvs (BAR) domain proteins with their …
Curving cells inside and out: roles of BAR domain proteins in membrane shaping and its cellular implications
M Simunovic, E Evergren… - Annual review of cell …, 2019 - annualreviews.org
Many cellular processes rely on precise and timely deformation of the cell membrane. While
many proteins participate in membrane reshaping and scission, usually in highly specialized …
many proteins participate in membrane reshaping and scission, usually in highly specialized …
Thermodynamics and mechanics of membrane curvature generation and sensing by proteins and lipids
Research investigating lipid membrane curvature generation and sensing is a rapidly
developing frontier in membrane physical chemistry and biophysics. The fast recent …
developing frontier in membrane physical chemistry and biophysics. The fast recent …
Mechanisms shaping cell membranes
Membranes of intracellular organelles are characterized by large curvatures with radii of the
order of 10–30 nm. While, generally, membrane curvature can be a consequence of any …
order of 10–30 nm. While, generally, membrane curvature can be a consequence of any …
Mechanism of membrane-curvature generation by ER-tubule shaping proteins
The endoplasmic reticulum (ER) network consists of tubules with high membrane curvature
in cross-section, generated by the reticulons and REEPs. These proteins have two pairs of …
in cross-section, generated by the reticulons and REEPs. These proteins have two pairs of …
What can machine learning do for antimicrobial peptides, and what can antimicrobial peptides do for machine learning?
Antimicrobial peptides (AMPs) are a diverse class of well-studied membrane-permeating
peptides with important functions in innate host defense. In this short review, we provide a …
peptides with important functions in innate host defense. In this short review, we provide a …
Interferon-induced transmembrane protein 3 blocks fusion of diverse enveloped viruses by altering mechanical properties of cell membranes
Interferon-induced transmembrane protein 3 (IFITM3) potently inhibits entry of diverse
enveloped viruses by trapping the viral fusion at a hemifusion stage, but the underlying …
enveloped viruses by trapping the viral fusion at a hemifusion stage, but the underlying …
Membrane tension controls the assembly of curvature-generating proteins
M Simunovic, GA Voth - Nature communications, 2015 - nature.com
Abstract Proteins containing a Bin/Amphiphysin/Rvs (BAR) domain regulate membrane
curvature in the cell. Recent simulations have revealed that BAR proteins assemble into …
curvature in the cell. Recent simulations have revealed that BAR proteins assemble into …