Context.—Prostate cancer remains a significant public health problem. Recent publications
of randomized trials and the US Preventive Services Task Force recommendations have …

In early breast cancer (eBC), established clinicopathological factors are not sufficient for
clinical decision making particularly regarding adjuvant chemotherapy since substantial …

Introduction Tumor cell interactions with the microenvironment, especially those of bone-
marrow-derived myeloid cells, are important in various aspects of tumor metastasis. Myeloid …

Background We previously reported that IL-6 and transglutaminase 2 (TG2) were expressed
in more aggressive basal-like breast cancer cells, and TG2 and IL-6 expression gave these …

Purpose Prior studies examining cost effectiveness of the 21-gene assay (Oncotype DX
[ODX]) for women with hormone receptor–positive, early-stage breast cancer have yielded …

Gene expression profiles with prognostic capacities have shown good performance in
multiple clinical trials. However, with multiple assays available and numerous types of …

Introduction The use of chemotherapy in node-negative,(O) Estrogen Receptor (ER)-positive
breast cancer has changed significantly since the introduction of Oncotype DX to determine …

Gene expression profiling tests are used in an attempt to determine the right treatment for
the right person with early-stage breast cancer that may have spread to nearby lymph nodes …

Adverse reactions in normal tissue after radiotherapy (RT) limit the dose that can be given to
tumour cells. Since 80% of individual variation in clinical response is estimated to be caused …

Background It is a challenge for oncologists to distinguish patients with breast cancer who
can forego adjuvant systemic treatment without negatively affecting survival from those who …