The concept of a prion as an infectious self-propagating protein isoform was initially
proposed to explain certain mammalian diseases. It is now clear that yeast also has …

Since the term protein was first coined in 1838 and protein was discovered to be the
essential component of fibrin and albumin, all cellular proteins were presumed to play …

Prions are agents of analog, protein conformation-based inheritance that can confer
beneficial phenotypes to cells, especially under stress. Combined with genetic variation …

In neurodegenerative diseases, polymorphism and supramolecular assembly of β-sheet
amyloids are implicated in many different etiologies and may adopt either a left-or right …

Background Amyloid-β plaques are a defining characteristic of Alzheimer Disease.
However, Amyloid-β deposition is also found in other forms of dementia and in non …

The epithelial–mesenchymal transition (EMT) is a cellular transdifferentiation program that
enables epithelial cancer cells to acquire traits of high-grade malignancy, notably invasive …

Background Prion proteins conform a special class among amyloids due to their ability to
transmit aggregative folds. Prions are known to act as infectious agents in …

Yeast prion [PSI+] is a self-perpetuating amyloid of the translational termination factor
Sup35. Although [PSI+] propagation is modulated by heat shock proteins (Hsps), high …

Yeast self-perpetuating amyloids (prions) provide a convenient model for studying the
cellular control of highly ordered aggregates involved in mammalian protein assembly …

Amyloid‐based prions have simple structures, a wide phylogenetic distribution, and a
plethora of functions in contemporary organisms, suggesting they may be an ancient …