Phosphatidylserine (PtdSer) is a phospholipid that is abundant in eukaryotic plasma
membranes. An ATP-dependent enzyme called flippase normally keeps PtdSer inside the …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

The TMEM16 family of proteins, also known as anoctamins, features a remarkable functional
diversity. This family contains the long sought-after Ca2+-activated chloride channels as well …

The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …

In this study, we combined linkage analysis with whole-exome sequencing of two individuals
to identify candidate causal variants in a moderately-sized UK kindred exhibiting autosomal …

Anoctamin (ANO)/TMEM16 proteins exhibit diverse functions in cells throughout the body
and are implicated in several human diseases. Although the founding members ANO1 …

The calcium-activated chloride channel TMEM16A is a member of a conserved protein
family that comprises ion channels and lipid scramblases. Although the structure of the …

Scramblases catalyze the movement of lipids between both leaflets of a bilayer. Whereas
the X-ray structure of the protein nhTMEM16 has previously revealed the architecture of a …

Rationale: Ca2+-activated Cl channels play pivotal roles in the cardiovascular system. They
regulate vascular smooth muscle tone and participate in cardiac action potential …

The Tmem16 gene family was first identified by bioinformatic analysis in 2004. In 2008, it
was shown independently by 3 laboratories that the first two members (Tmem16A and …