[HTML][HTML] Role of FGFR3 in bladder cancer: Treatment landscape and future challenges

CM Ascione, F Napolitano, D Esposito… - Cancer Treatment …, 2023 - Elsevier
Bladder cancer is a heterogeneous malignancy and is responsible for approximately 3.2%
of new diagnoses of cancer per year (Sung et al., 2021). Fibroblast Growth Factor Receptors …

The fibroblast growth factor signaling pathway

DM Ornitz, N Itoh - Wiley Interdisciplinary Reviews …, 2015 - Wiley Online Library
The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

[HTML][HTML] Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application

YK Chae, K Ranganath, PS Hammerman, C Vaklavas… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) is a tyrosine kinase
signaling pathway that has a fundamental role in many biologic processes including …

Receptor specificity of the fibroblast growth factor family

DM Ornitz, J Xu, JS Colvin, DG McEwen… - Journal of Biological …, 1996 - ASBMB
Fibroblast growth factors (FGFs) are essential molecules for mammalian development. The
nine known FGF ligands and the four signaling FGF receptors (and their alternatively spliced …

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

R Shiang, LM Thompson, YZ Zhu, DM Church… - Cell, 1994 - cell.com
Achondroplasia(ACH) is the most common genetic form of dwarfism. This disorder is
inherited as an autosomal dominant trait, although the majority of cases are sporadic. A …

Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity

D Schmucker, JC Clemens, H Shu, CA Worby, J Xiao… - Cell, 2000 - cell.com
A Drosophila homolog of human Down syndrome cell adhesion molecule (DSCAM), an
immunoglobulin superfamily member, was isolated by its affinity to Dock, an SH3/SH2 …

Biological roles of fibroblast growth factor-2

A Bikfalvi, S Klein, G Pintucci, DB Rifkin - Endocrine reviews, 1997 - academic.oup.com
Biological Roles of Fibroblast Growth Factor-2* | Endocrine Reviews | Oxford Academic
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[PDF][PDF] PROTEIN-TYROSINE KINASES AND THEIR SIGNAL TRANSDUCTION PATHWAYS

P Van der Geer, T Hunter - Annu. Rev. Cell Biol, 1994 - researchgate.net
Cells modulate their activities in response to signals from their surrounding environment.
Single cell organisms respond mainly to nutrient cues, many of which are able to cross the …

Structural and functional diversity in the FGF receptor multigene family

DE Johnson, LT Williams - Advances in cancer research, 1992 - Elsevier
Publisher Summary The fibroblast growth factors (FGFs) constitute a family of closely related
polypeptide mitogens. There are seven members of this family, identified on the basis of …

α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors

SC Robins, I Stewart, DE McNay, V Taylor… - Nature …, 2013 - nature.com
Emerging evidence suggests that new cells, including neurons, can be generated within the
adult hypothalamus, suggesting the existence of a local neural stem/progenitor cell niche …