Mechanisms of feedback regulation of vitamin A metabolism

C O'Connor, P Varshosaz, AR Moise - Nutrients, 2022 - mdpi.com
Vitamin A is an essential nutrient required throughout life. Through its various metabolites,
vitamin A sustains fetal development, immunity, vision, and the maintenance, regulation, and …

Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions

SP Rendić, RD Crouch, FP Guengerich - Archives of Toxicology, 2022 - Springer
This is an overview of the metabolic reactions of drugs, natural products, physiological
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …

Cytosolic enzymes generate cannabinoid metabolites 7-carboxycannabidiol and 11-nor-9-carboxytetrahydrocannabinol

JL Beers, AK Authement, N Isoherranen… - ACS Medicinal …, 2023 - ACS Publications
The cannabinoids cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) undergo
extensive oxidative metabolism in the liver. Although cytochromes P450 form the primary …

Does the micronutrient molybdenum have a role in gestational complications and placental health?

V Foteva, JJ Fisher, Y Qiao, R Smith - Nutrients, 2023 - mdpi.com
Molybdenum is an essential trace element for human health and survival, with molybdenum-
containing enzymes catalysing multiple reactions in the metabolism of purines, aldehydes …

[HTML][HTML] p-Hydroxybenzoic acid alleviates inflammatory responses and intestinal mucosal damage in DSS-induced colitis by activating ERβ signaling

X Xu, A Luo, X Lu, M Liu, H Wang, H Song… - Journal of Functional …, 2021 - Elsevier
Abstract p-Hydroxybenzaldehyde (HD), the main active component of Nostoc commune, has
been shown to attenuate dextran sulfate sodium (DSS)-induced experimental colitis …

[HTML][HTML] Knockout of Sema4D alleviates liver fibrosis by suppressing AOX1 expression

L Wang, D Li, Z Zhu, Y Liao, J Wu, Y Liu, R Yang… - Pharmacological …, 2023 - Elsevier
Liver fibrosis can occur in many chronic liver diseases, and no effective treatments are
available due to the poorly characterized molecular pathogenesis. Semaphorin 4D …

Raloxifene and bazedoxifene as selective ALDH1A1 inhibitors to ameliorate cyclophosphamide resistance: A drug repurposing approach

G Narendra, B Raju, H Verma, M Kumar, SK Jain… - International Journal of …, 2023 - Elsevier
Cyclophosphamide (CP) is one of the most widely used anticancer drugs for various
malignancies. However, its long-term use leads to ALDH1A1-mediated inactivation and …

Vitamin A homeostasis and cardiometabolic disease in humans: lost in translation?

AS Yadav, N Isoherranen… - Journal of molecular …, 2022 - jme.bioscientifica.com
Vitamin A (retinol) is an essential, fat-soluble vitamin that plays critical roles in embryonic
development, vision, immunity, and reproduction. Severe vitamin A deficiency results in …

Role of AOX1 on RXR signaling regulates osteoblastogenesis in hPDLMSCs

S Sun, T Iwata - Scientific Reports, 2024 - nature.com
Alveolar bone loss resulting from periodontal disease ultimately leads to tooth loss.
Periodontal ligament mesenchymal stem cells (PDLMSCs) are the tissue-specific cells …

Raw potato starch alters the microbiome, colon and cecal gene expression, and resistance to Citrobacter rodentium infection in mice fed a Western diet

AD Smith, C Chen, L Cheung, HD Dawson - Frontiers in Nutrition, 2023 - frontiersin.org
Resistant starches (RS) are fermented in the cecum and colon to produce short-chain fatty
acids and other microbial metabolites that can alter host physiology and the composition of …