The use of biomarkers in diagnosis, therapy and prognosis has gained increasing interest
over the last decades. In particular, the analysis of biomarkers in cancer patients within the …

Tumor cell vasculogenic mimicry (VM), also dubbed vascular mimicry, describes the
plasticity of aggressive cancer cells forming de novo vascular networks and is associated …

Solid tumors can be divided into benign solid tumors and solid malignant tumors in the
academic community, among which malignant solid tumors are called cancers. Cancer is …

Long non-coding RNAs (lncRNAs) represent a class of epigenetic regulators implicated in a
number of physiological and pathological conditions. Herein, we characterized the lncRNA …

Despite the recent advances in cancer patient management and in the development of
targeted therapies, systemic chemotherapy is currently used as a first-line treatment for …

Background Zoledronic acid is the most potent osteoclast inhibitor and is widely used for
advanced cancer patients with bone metastasis, but its role on cancer stem cells (CSCs) …

Dysregulated glycolysis is one of the mechanisms employed by cancer cells to facilitate
growth and metastasis. Here we aimed to characterize the PPFIA4 gene, as a glycolysis …

Small-cell lung cancer (SCLC) represents 15% of all lung cancers and it is clinically the most
aggressive type, being characterized by a tendency for early metastasis, with two-thirds of …

Small-molecule-inhibitor-based bone differentiation has been recently exploited as a novel
approach to regulating osteogenesis-related signaling pathways. In this study, we identified …

Background Aldehyde dehydrogenase 1A1 (ALDH1A1) encodes an enzyme that oxidizes
aldehydes to their corresponding carboxylic acids. In colorectal cancer ALDH1A1 marks …